1678-14-4
1678-14-4 structure
- Name: 4H-Pyran-4-one,2,6-bis(4-methoxyphenyl)-
- Chemical Name: 2,6-bis(4-methoxyphenyl)pyran-4-one
- CAS Number: 1678-14-4
- Molecular Formula: C19H16O4
- Molecular Weight: 308.32800
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2017-10-17 02:16:40
- Modify Date: 2024-01-09 01:09:21
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NSC81111 is a potent and orally active EGFR-TK inhibitor with an IC50 of 0.15 nM. NSC81111 has anticaner effects[1].
| Name | 2,6-bis(4-methoxyphenyl)pyran-4-one |
|---|---|
| Synonyms |
2,6-bis-(4-methoxy-phenyl)-pyran-4-one
4H-Pyran-4-one,2,6-bis(p-methoxyphenyl) 2,6-bis(4-methoxyphenyl)-4H-pyran-4-one 2.6-Bis-<4-methoxy-phenyl>-4-pyron 2,6-Bis-(4-methoxy-phenyl)-pyran-4-on 2,6-di-(4-methoxyphenyl)-4H-pyran-4-one 2.6-Di-<4-methoxy-phenyl>-4-pyron |
| Description | NSC81111 is a potent and orally active EGFR-TK inhibitor with an IC50 of 0.15 nM. NSC81111 has anticaner effects[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.15 nM (EGFR-TK)[1] |
| References |
| Density | 1.218g/cm3 |
|---|---|
| Boiling Point | 528.3ºC at 760mmHg |
| Molecular Formula | C19H16O4 |
| Molecular Weight | 308.32800 |
| Flash Point | 235.1ºC |
| Exact Mass | 308.10500 |
| PSA | 48.67000 |
| LogP | 3.99100 |
| Vapour Pressure | 3.01E-11mmHg at 25°C |
| Index of Refraction | 1.597 |
|
~84%
1678-14-4 |
| Literature: Knight, John D.; Metz, Clyde R.; Beam, Charles F.; Pennington, William T.; VanDerveer, Donald G. Synthetic Communications, 2008 , vol. 38, # 14 p. 2465 - 2482 |
|
~21%
1678-14-4 |
| Literature: Saitoh; Oyama; Sakurai; Niimura; Hinata; Horiguchi; Toda; Sano Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 5 p. 956 - 966 |
|
~%
1678-14-4 |
| Literature: Saitoh; Oyama; Sakurai; Niimura; Hinata; Horiguchi; Toda; Sano Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 5 p. 956 - 966 |
|
~%
1678-14-4 |
| Literature: Saitoh; Oyama; Sakurai; Niimura; Hinata; Horiguchi; Toda; Sano Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 5 p. 956 - 966 |
|
~%
1678-14-4 |
| Literature: El-Kholy et al. Journal of the Chemical Society, 1959 , p. 2588,2591 |
| Precursor 5 | Previous 1/2 Next |
|---|---|
| DownStream 2 | |
