1678-14-4

1678-14-4 structure

Name: 4H-Pyran-4-one,2,6-bis(4-methoxyphenyl)-
Chemical Name: 2,6-bis(4-methoxyphenyl)pyran-4-one
CAS Number: 1678-14-4
Molecular Formula: C₁₉H₁₆O₄
Molecular Weight: 308.32800
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2017-10-17 02:16:40
Modify Date: 2025-08-25 20:09:53
NSC81111 is a potent and orally active EGFR-TK inhibitor with an IC50 of 0.15 nM. NSC81111 has anticaner effects[1].

Name	2,6-bis(4-methoxyphenyl)pyran-4-one
Synonyms	2,6-bis-(4-methoxy-phenyl)-pyran-4-one 4H-Pyran-4-one,2,6-bis(p-methoxyphenyl) 2,6-bis(4-methoxyphenyl)-4H-pyran-4-one 2.6-Bis-<4-methoxy-phenyl>-4-pyron 2,6-Bis-(4-methoxy-phenyl)-pyran-4-on 2,6-di-(4-methoxyphenyl)-4H-pyran-4-one 2.6-Di-<4-methoxy-phenyl>-4-pyron

Description	NSC81111 is a potent and orally active EGFR-TK inhibitor with an IC50 of 0.15 nM. NSC81111 has anticaner effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	IC50: 0.15 nM (EGFR-TK)[1]
References	[1]. Nattanan Jiwacharoenchai, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg Med Chem Lett. 2022 Feb 15;58:128524.

1469-93-8

~84%

1678-14-4

55991-65-6

55991-69-0

~21%

1678-14-4

Literature: Saitoh; Oyama; Sakurai; Niimura; Hinata; Horiguchi; Toda; Sano Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 5 p. 956 - 966

100-06-1

1678-14-4

Literature: Saitoh; Oyama; Sakurai; Niimura; Hinata; Horiguchi; Toda; Sano Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 5 p. 956 - 966

55991-65-6

1678-14-4

Literature: Saitoh; Oyama; Sakurai; Niimura; Hinata; Horiguchi; Toda; Sano Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 5 p. 956 - 966

51718-85-5

1678-14-4

Literature: El-Kholy et al. Journal of the Chemical Society, 1959 , p. 2588,2591