Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: 3-Pyridinemethanol,5-hydroxy-4,6-dimethyl-, 3-(dihydrogen phosphate)
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883-84-1

883-84-1 structure

Name: 4-Deoxypyridoxine 5'-phosphate
Chemical Name: (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate
CAS Number: 883-84-1
Molecular Formula: C₈H₁₂NO₅P
Molecular Weight: 233.15800
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2017-12-15 02:41:00
Modify Date: 2024-01-12 17:33:26
4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase[1][2][3].

Name	(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate
Synonyms	1ggn vitamin B-6 PLR Deoxypyridoxine-P 4-Deoxypyridoxine 5'-phosphate 4-Desoxy-pyridoxol-phosphat 4-Deoxypyridoxin-5'-phosphat

Description	4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Metabolic Disease
Target	Sphingosine 1-phosphate (S1P)[1] Ornithine decarboxylase[2] Glutamate apodecarboxylase[3]
References	[1]. Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216. [2]. M J Connor, et al. Epidermal Pyridoxal 5'-phosphate Depletion, Inhibition of DNA Synthesis, and Inhibition of the Expression of Ornithine Decarboxylase Activity by the Vitamin B-6 Antagonist 4'-deoxypyridoxine. J Invest Dermatol. 1983 Aug;81(2):136-9. [3]. D L Martin, et al. Glutamate-dependent Active-Site Labeling of Brain Glutamate Decarboxylase. J Neurochem. 1990 Aug;55(2):524-32.

Hazard Codes	Xi
HS Code	2933399090

61-67-6

883-84-1

Literature: Nation.Drug Co. Patent: US2511319 , 1947 ;

57183-08-1

883-84-1

Literature: Long; Morrison Journal of the Chemical Society, 1954 , p. 3854

Precursor 2
61-67-6 57183-08-1
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%