22242-96-2

22242-96-2 structure

Name: Jaspamycin
Chemical Name: 1,3-benzodioxol-2-one
CAS Number: 22242-96-2
Molecular Formula: C₁₂H₁₂N₄O₅
Molecular Weight: 292.25
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK PKA
Create Date: 2016-01-02 19:23:53
Modify Date: 2024-01-20 19:18:48
Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].

Name	1,3-benzodioxol-2-one
Synonyms	6-Phenyl-5-cyan-uracil 5-Cyano-6-phenyl-2,4(1H,3H)-pyrimidinedione 5-Cyano-2,4-dioxo-6-phenyl-1,2,3,4-tetrahydro-pyrimidin 5-Cyano-6-phenyluracil 2,4-dioxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

Description	Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA
Target	Trypanosoma brucei PKAR(199-499):6.5 nM (EC50) Trypanosoma brucei PKA holoenzyme:8 nM (Kd)
References	[1]. Sabine Bachmaier, et al. Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun. 2019 Mar 29;10(1):1421.