Jaspamycin

Modify Date: 2024-01-20 19:18:48

Jaspamycin structure	Common Name	Jaspamycin
	CAS Number	22242-96-2	Molecular Weight	292.25
	Density	1.91g/cm3	Boiling Point	724.3ºC at 760 mmHg
	Molecular Formula	C₁₂H₁₂N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	391.8ºC

Use of Jaspamycin

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].

Name	1,3-benzodioxol-2-one
Synonym	More Synonyms

Description	Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA
Target	Trypanosoma brucei PKAR(199-499):6.5 nM (EC50) Trypanosoma brucei PKA holoenzyme:8 nM (Kd)
References	[1]. Sabine Bachmaier, et al. Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun. 2019 Mar 29;10(1):1421.

Density	1.91g/cm3
Boiling Point	724.3ºC at 760 mmHg
Molecular Formula	C₁₂H₁₂N₄O₅
Molecular Weight	292.25
Flash Point	391.8ºC
Exact Mass	292.08100
PSA	144.39000
Vapour Pressure	5.1E-22mmHg at 25°C
Index of Refraction	1.827

Precursor 0
DownStream 7
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