89226-50-6

89226-50-6 structure

Name: Manidipine
Chemical Name: 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number: 89226-50-6
Molecular Formula: C₃₅H₃₈N₄O₆
Molecular Weight: 610.699
Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
Create Date: 2018-05-28 08:00:00
Modify Date: 2024-01-02 12:56:50
Manidipine is a calcium channel blocker that is used clinically as an antihypertensive. Target: Calcium ChannelManidipine is a dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine was well tolerated in clinical trials, with most adverse effects related to vasodilation [1]. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension [2]. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension [3].

Name	3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms	2-[4-(Diphenylmethyl)-1-piperazinyl]ethylmethyl (±)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylate 2-[4-(diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate 3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Manidipine 6300 Manidipine UNII:6O4754US88 CV-4093,2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Manidipine (Manyper) 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (+/-)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester 2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Franidipine 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester

Description	Manidipine is a calcium channel blocker that is used clinically as an antihypertensive. Target: Calcium ChannelManidipine is a dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine was well tolerated in clinical trials, with most adverse effects related to vasodilation [1]. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension [2]. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension [3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
References	[1]. Cheer, S.M. and K. McClellan, Manidipine: a review of its use in hypertension. Drugs, 2001. 61(12): p. 1777-99. [2]. McKeage, K. and L.J. Scott, Manidipine: a review of its use in the management of hypertension. Drugs, 2004. 64(17): p. 1923-40. [3]. Roca-Cusachs, A. and F. Triposkiadis, Antihypertensive effect of manidipine. Drugs, 2005. 65 Suppl 2: p. 11-9.

Density	1.2±0.1 g/cm3
Boiling Point	722.0±60.0 °C at 760 mmHg
Melting Point	125-128ºC
Molecular Formula	C₃₅H₃₈N₄O₆
Molecular Weight	610.699
Flash Point	390.4±32.9 °C
Exact Mass	610.279114
PSA	116.93000
LogP	5.46
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.601
Storage condition	-20°C Freezer

Hazard Codes	Xi

10527-64-7

74936-72-4

89226-50-6

Literature: WO2011/23954 A2, ; Page/Page column 18 ;

99-61-6

89226-49-3

14205-39-1

~77%

89226-50-6

Literature: Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797

10527-64-7

89226-50-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797

841-77-0

89226-50-6

Literature: WO2011/23954 A2, ;

89226-49-3

89226-50-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797

90120-00-6

14205-39-1

89226-50-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797

Precursor 7
10527-64-7 74936-72-4 99-61-6 89226-49-3
14205-39-1 841-77-0 90120-00-6
DownStream 1
89226-75-5

89226-50-6	120092-68-4
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104196-68-1	133082-19-6
89226-75-5	126451-47-6
104305-93-3	1217836-12-8
1158522-08-7	940364-43-2
134104-43-1	2680872-77-7
131615-57-1	2172074-19-8
6906-52-1	930439-75-1
1018584-77-4	2171266-73-0