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15266-38-3

15266-38-3 structure
15266-38-3 structure
  • Name: Evocarpine
  • Chemical Name: (Z)-1-Methyl-2-(tridec-8-en-1-yl)quinolin-4(1H)-one
  • CAS Number: 15266-38-3
  • Molecular Formula: C23H33NO
  • Molecular Weight: 339.514
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-02-20 08:00:00
  • Modify Date: 2025-08-22 09:55:30
  • Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca2+ influx through voltage-dependent calcium channels. Antimycobacterial activity[1][2].
Name (Z)-1-Methyl-2-(tridec-8-en-1-yl)quinolin-4(1H)-one
Synonyms 4(1H)-Quinolinone, 1-methyl-2-(8-tridecenyl)-, (Z)-
4(1H)-Quinolinone, 1-methyl-2-[(8Z)-8-tridecen-1-yl]-
1-Methyl-2-[(8Z)-8-tridecen-1-yl]-4(1H)-quinolinone
evocarpine
Description Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca2+ influx through voltage-dependent calcium channels. Antimycobacterial activity[1][2].
Related Catalog
In Vitro Cumulative application of evocarpine (1-100 μM) inhibits the sustained contraction induced by 60 mM K+ in a concentration-dependent manner[1]. Evocarpine is found to induce apoptotic cell death in promyelocytic leukaemia HL‐60 cells in dose- and time-dependent manners[3].
References

[1]. J Yamahar, et al. The vasorelaxant effect of evocarpine in isolated aortic strips: mode of action. Eur J Pharmacol. 1988 Oct 11;155(1-2):139-43.

[2]. C Hochfellner, et al. Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine. J Appl Microbiol. 2015 Apr;118(4):864-72.

[3]. N Y Kim, et al. Cyclic adenosine monophosphate inhibits quinolone alkaloid evocarpine-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. Pharmacol Toxicol. 2000 Jul;87(1):1-5.
Density 1.0±0.1 g/cm3
Boiling Point 456.2±45.0 °C at 760 mmHg
Melting Point 34-38℃
Molecular Formula C23H33NO
Molecular Weight 339.514
Flash Point 156.1±18.1 °C
Exact Mass 339.256226
PSA 22.00000
LogP 7.70
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.526
Storage condition 2-8C
98321-50-7 structure

98321-50-7

~90%

15266-38-3 structure

15266-38-3

Literature: Coppola, Gary M. Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 491 - 494
17696-11-6 structure

17696-11-6

~%

15266-38-3 structure

15266-38-3

Literature: Journal of Heterocyclic Chemistry, , vol. 22, p. 491 - 494
55182-92-8 structure

55182-92-8

~%

15266-38-3 structure

15266-38-3

Literature: Journal of Heterocyclic Chemistry, , vol. 22, p. 491 - 494
98321-46-1 structure

98321-46-1

~%

15266-38-3 structure

15266-38-3

Literature: Journal of Heterocyclic Chemistry, , vol. 22, p. 491 - 494
693-02-7 structure

693-02-7

~%

15266-38-3 structure

15266-38-3

Literature: Journal of Heterocyclic Chemistry, , vol. 22, p. 491 - 494
Precursor  3

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