15266-38-3

15266-38-3 structure

Name: Evocarpine
Chemical Name: (Z)-1-Methyl-2-(tridec-8-en-1-yl)quinolin-4(1H)-one
CAS Number: 15266-38-3
Molecular Formula: C₂₃H₃₃NO
Molecular Weight: 339.514
Catalog: Biochemical Plant extracts
Create Date: 2018-02-20 08:00:00
Modify Date: 2024-01-04 11:58:41
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca2+ influx through voltage-dependent calcium channels. Antimycobacterial activity[1][2].

Name	(Z)-1-Methyl-2-(tridec-8-en-1-yl)quinolin-4(1H)-one
Synonyms	4(1H)-Quinolinone, 1-methyl-2-(8-tridecenyl)-, (Z)- 4(1H)-Quinolinone, 1-methyl-2-[(8Z)-8-tridecen-1-yl]- 1-Methyl-2-[(8Z)-8-tridecen-1-yl]-4(1H)-quinolinone evocarpine

Description	Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca2+ influx through voltage-dependent calcium channels. Antimycobacterial activity[1][2].
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In Vitro	Cumulative application of evocarpine (1-100 μM) inhibits the sustained contraction induced by 60 mM K+ in a concentration-dependent manner[1]. Evocarpine is found to induce apoptotic cell death in promyelocytic leukaemia HL‐60 cells in dose- and time-dependent manners[3].
References	[1]. J Yamahar, et al. The vasorelaxant effect of evocarpine in isolated aortic strips: mode of action. Eur J Pharmacol. 1988 Oct 11;155(1-2):139-43. [2]. C Hochfellner, et al. Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine. J Appl Microbiol. 2015 Apr;118(4):864-72. [3]. N Y Kim, et al. Cyclic adenosine monophosphate inhibits quinolone alkaloid evocarpine-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. Pharmacol Toxicol. 2000 Jul;87(1):1-5.