129693-13-6

129693-13-6 structure

Name: Sp-8-pCPT-cAMPS
Chemical Name: 8-(4-chlorophenylthio) adenosine-3',5'-cyclic monophosphorothioate, sp-isomer sodium salt
CAS Number: 129693-13-6
Molecular Formula: C₁₆H₁₄ClN₅NaO₅PS₂
Molecular Weight: 509.85900
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK PKA
Create Date: 2017-04-18 17:41:26
Modify Date: 2024-01-11 18:28:23
Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold[1][2].

Name	8-(4-chlorophenylthio) adenosine-3',5'-cyclic monophosphorothioate, sp-isomer sodium salt

Description	Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	PKA[1]
In Vitro	Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells[2]. Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells[2]. Sp-8-CPT-cAMPS (10 μM; 30 min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis[3].
References	[1]. Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. [2]. Boese M, et, al. Effect of cyclic GMP-dependent vasodilators on the expression of inducible nitric oxide synthase in vascular smooth muscle cells: role of cyclic AMP. Br J Pharmacol. 1996 Oct;119(4):707-15. [3]. Spicuzza L, et, al. Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol. 2001 Aug;133(8):1201-12.

Molecular Formula	C₁₆H₁₄ClN₅NaO₅PS₂
Molecular Weight	509.85900
Exact Mass	508.97600
PSA	207.80000
LogP	3.77360

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