61545-06-0

61545-06-0 structure

Name: Temocillin disodium salt
Chemical Name: temocillin disodium
CAS Number: 61545-06-0
Molecular Formula: C₁₆H₁₆N₂Na₂O₇S₂
Molecular Weight: 458.42
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-07-05 22:36:30
Modify Date: 2024-01-21 11:33:52
Temocillin disodium, a 6-α-methoxy penicillin, possesses antibacterial activity[1].

Name	temocillin disodium
Synonyms	4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,6-((carboxy-3-thienylacetyl)amino)-6-methoxy-3,3-dimethyl-7-oxo-,disodium salt,(2S,5R,6S) disodium,(2S,5R,6S)-6-[(2-carboxylato-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate UNII-96IIP39ODH Negaban (TN) Temocillin disodium salt EINECS 262-835-9 Temocillin sodium Temocillin

Description	Temocillin disodium, a 6-α-methoxy penicillin, possesses antibacterial activity[1].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vivo	Temocillin dosing regimens of 200 mg/kg every 4 and 6 h remained significantly effective in reducing bacterial titres in kidneys against the two strains, with no significant difference between the parental strain and its transconjugant[2].
References	[1]. K Jules, et al. Antibacterial activity and beta-lactamase stability of temocillin. Antimicrob Agents Chemother. 1982 Sep;22(3):453-60. [2]. J F Soubirou, et al. Activity of temocillin in a murine model of urinary tract infection due to Escherichia coli producing or not producing the ESBL CTX-M-15. J Antimicrob Chemother. 2015 May;70(5):1466-72.