Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 9-(6-Amino-3-pyridinyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one
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Purity: 98.0%
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1223002-54-7

1223002-54-7 structure

Name: QL-IX-55
Chemical Name: 9-(6-aminopyridin-3-yl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one
CAS Number: 1223002-54-7
Molecular Formula: C₂₄H₁₄F₄N₄O
Molecular Weight: 450.39
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2017-12-21 07:05:07
Modify Date: 2024-01-16 01:13:58
QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC50s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively.

Name	9-(6-aminopyridin-3-yl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one
Synonyms	QL-IX-55 CS-0703 9-(6-aminopyridin-3-yl)-1-(4-fluoro-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one

Description	QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC50s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively.
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer
References	[1]. Liu Q, Ren T, Fresques T, Oppliger W, Niles BJ, Hur W, Sabatini DM, Hall MN, Powers T, Gray NS.Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae.ACS Chem Biol. 2012 Jun 15;7(6):982-7.