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  • BioBioPha
  • China
  • Product Name: hinokiflavone
  • Price: ¥Inquiry/5mg
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng



19202-36-9

19202-36-9 structure
19202-36-9 structure
  • Name: hinokiflavone
  • Chemical Name: hinokiflavone
  • CAS Number: 19202-36-9
  • Molecular Formula: C30H18O10
  • Molecular Weight: 538.458
  • Catalog: Natural product Flavonoids
  • Create Date: 2018-03-31 08:00:00
  • Modify Date: 2024-01-05 15:05:16
  • Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity[1].

Name hinokiflavone
Synonyms 6-[4-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
hynokiflavone
hinokiflavone
4H-1-Benzopyran-4-one, 6-(4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
4',6''-O-Biapigenin
6-[4-(5,7-dihydroxy-4-oxochromen-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
6-(4-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
4',6"-O-Biapigenin
4H-1-Benzopyran-4-one, 6-[4-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
Description Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity[1].
Related Catalog
References

[1]. Pawellek A, et al. Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. Elife. 2017 Sep 8;6. pii: e27402.

Density 1.6±0.1 g/cm3
Boiling Point 841.5±65.0 °C at 760 mmHg
Melting Point 353-355ºC
Molecular Formula C30H18O10
Molecular Weight 538.458
Flash Point 284.8±27.8 °C
Exact Mass 538.090027
PSA 170.80000
LogP 4.33
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.771
Storage condition 2-8℃
Hazard Codes Xi