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183293-82-5

183293-82-5 structure
183293-82-5 structure
  • Name: Gemcabene
  • Chemical Name: 6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid
  • CAS Number: 183293-82-5
  • Molecular Formula: C16H30O5
  • Molecular Weight: 302.40600
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2016-03-23 01:59:34
  • Modify Date: 2024-02-18 19:08:26
  • Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].

Name 6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid
Synonyms Gemcabene
UNII-B96UX1DDKS
Description Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].
Related Catalog
In Vitro Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2)[3].
References

[1]. Mandema JW, et al. Model-based development of gemcabene, a new lipid-altering agent. AAPS J. 2005 Oct 7;7(3):E513-22.

[2]. Srivastava RAK, et al. Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain. Front Pharmacol. 2018 May 11;9:471.

[3]. Oniciu DC, et al. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. PLoS One. 2018 May 30;13(5):e0194568.

Density 1.048g/cm3
Boiling Point 453.6ºC at 760mmHg
Molecular Formula C16H30O5
Molecular Weight 302.40600
Flash Point 156.7ºC
Exact Mass 302.20900
PSA 83.83000
LogP 3.56520
Vapour Pressure 1.72E-09mmHg at 25°C
Index of Refraction 1.473
Storage condition 2-8℃

~57%

183293-82-5 structure

183293-82-5

Literature: SSV THERAPEUTICS, INC. Patent: WO2008/18877 A1, 2008 ; Location in patent: Page/Page column 38 ;

~30%

183293-82-5 structure

183293-82-5

Literature: Zhang, Yinsheng; Jian, Zhigang; Hong, Yang Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 5-6 p. 602 - 604