Name | ethyl (E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-methyl-1,2-oxazole-3-carbonyl)amino]-4-oxoheptanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate |
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Synonyms |
ag7088
UNII-RGE5K1Q5QW Ruprintrivir Rupintrivir |
Description | Rupintrivirvr (AG7088), an antiviral drug, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect[1][2]. |
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Related Catalog | |
In Vitro | In H1-HeLa and MRC-5 cell protection assays, Rupintrivirvr (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC50) of 0.023 μM (range, 0.003 to 0.081 μM) and a mean EC90 of 0.082 μM (range, 0.018 to 0.261 μM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11[1]. |
In Vivo | Rupintrivirvr (AG7088) reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo[2]. |
References |
Density | 1.213g/cm3 |
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Boiling Point | 866.7ºC at 760mmHg |
Melting Point | 170-171°C |
Molecular Formula | C31H39FN4O7 |
Molecular Weight | 598.66200 |
Flash Point | 477.9ºC |
Exact Mass | 598.28000 |
PSA | 156.70000 |
LogP | 3.93550 |
Vapour Pressure | 1.87E-30mmHg at 25°C |
Index of Refraction | 1.537 |
RIDADR | NONH for all modes of transport |
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