60940-34-3

60940-34-3 structure

Name: Ebselen
Chemical Name: ebselen
CAS Number: 60940-34-3
Molecular Formula: C₁₃H₉NOSe
Molecular Weight: 274.177
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-07-12 18:01:54
Modify Date: 2024-01-04 17:10:20
Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.Target:Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2]

Name	ebselen
Synonyms	2-Phenyl-1,2-benzoselenazol-3(2H)-one 1,2-Benzisoselenazol-3(2H)-one, 2-phenyl- Ebselenum 2-phenyl-1,2-benzoselenazol-3-one Harmokisane Ebselen MFCD00210937 Ebseleno Ebselene

Description	Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.Target:Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2]
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> HIV Research Areas >> Inflammation/Immunology
References	[1]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208. [2]. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971

Symbol	GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H301-H331-H373-H410
Precautionary Statements	P261-P273-P301 + P310-P311-P501
Hazard Codes	T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases	R23/25;R33;R50/53
Safety Phrases	S20/21-S28-S45-S60-S61-S28A
RIDADR	UN 3283 6.1/PG 3
WGK Germany	3
RTECS	DE4140750
HS Code	2927000090

HS Code	2927000090
Summary	2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%