485842-97-5
485842-97-5 structure
- Name: PMX464
- Chemical Name: 4-(1,3-benzothiazol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-one
- CAS Number: 485842-97-5
- Molecular Formula: C13H9NO2S
- Molecular Weight: 243.28
- Catalog: Research Areas Cancer
- Create Date: 2016-02-12 01:28:49
- Modify Date: 2025-08-25 18:26:39
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PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1].
| Name | 4-(1,3-benzothiazol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-one |
|---|---|
| Synonyms |
UNII-YJX11V636Q
PMX-464 AW-464 Threo-methylphenidate hydrochloride |
| Description | PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C13H9NO2S |
|---|---|
| Molecular Weight | 243.28 |
| Exact Mass | 243.03500 |
| PSA | 78.43000 |
| LogP | 2.17900 |
|
~53%
485842-97-5 |
| Literature: Wells, Geoffrey; Berry, Jane M.; Bradshaw, Tracey D.; Burger, Angelika M.; Seaton, Angela; Wang, Bo; Westwell, Andrew D.; Stevens, Malcolm F. G. Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 532 - 541 |
|
~%
485842-97-5 |
| Literature: Wells, Geoffrey; Berry, Jane M.; Bradshaw, Tracey D.; Burger, Angelika M.; Seaton, Angela; Wang, Bo; Westwell, Andrew D.; Stevens, Malcolm F. G. Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 532 - 541 |
|
~%
485842-97-5 |
| Literature: Chakraborty, Mrinal; Jin, Kyoung Joo; Glover, Stephen A.; Novak, Michael Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5296 - 5304 |
