PMX464

Modify Date: 2024-01-09 10:16:47

PMX464 structure	Common Name	PMX464
	CAS Number	485842-97-5	Molecular Weight	243.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₉NO₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PMX464

PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1].

Name	4-(1,3-benzothiazol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-one
Synonym	More Synonyms

Description	PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Callister ME, et, al. PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells. Br J Pharmacol. 2008 Nov;155(5):661-72.

Molecular Formula	C₁₃H₉NO₂S
Molecular Weight	243.28
Exact Mass	243.03500
PSA	78.43000
LogP	2.17900

Phenol,4-(2-ben...

CAS#:6265-55-0

~53%

PMX464

CAS#:485842-97-5

Literature: Wells, Geoffrey; Berry, Jane M.; Bradshaw, Tracey D.; Burger, Angelika M.; Seaton, Angela; Wang, Bo; Westwell, Andrew D.; Stevens, Malcolm F. G. Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 532 - 541