SRT 2183
Modify Date: 2025-08-25 17:53:53
SRT 2183 structure
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Common Name | SRT 2183 | ||
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| CAS Number | 1001908-89-9 | Molecular Weight | 468.57 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H24N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SRT 2183SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM[1]. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels[2]. |
| Name | srt2183 |
|---|
| Description | SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM[1]. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels[2]. |
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| Related Catalog | |
| Target |
SIRT1:0.36 μM (EC1.5) |
| In Vitro | SRT 2183 (1-10 μM; 24-72 hours) inhibits the growth of Reh and Nalm-6 cells in a time- and dose-dependent manner[2]. SRT 2183 (5-10 μM in Reh cells; 10 μM in Ly3 cells; 24 hours) induces expression of DNA-damage response genes associated with accumulation of phospho-H2A.X levels[2]. SRT2183 inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival[3]. Cell Proliferation Assay[2] Cell Line: Reh cells, Nalm-6 cells (pre-B acute lymphoblastic leukemia (ALL) cell lines) Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 24 hours, 48 hours, 72 hours Result: Inhibited the growth of Reh and Nalm-6 cells in a time- and dose-dependent manner. The IC50 (median inhibition concentration) values for SRT 2183-mediated inhibition of proliferation at 48 h are approximately 8.7 μM for Reh cells and approximately 3.2 μM for Nalm-6 cells. Western Blot Analysis[2] Cell Line: Reh cells, Ly3 cells Concentration: 5μM and 10μM (Reh cells); 10μM (Ly3 cells) Incubation Time: 24 hours Result: Induced accumulation of phospho-H2A.X in Reh as well as in Ly3 cells. |
| References |
| Molecular Formula | C27H24N4O2S |
|---|---|
| Molecular Weight | 468.57 |
| Exact Mass | 468.16200 |
| PSA | 98.11000 |
| LogP | 5.04580 |
| InChIKey | MUFSINOSQBMSLE-JOCHJYFZSA-N |
| SMILES | O=C(Nc1ccccc1-c1cn2c(CN3CCC(O)C3)csc2n1)c1ccc2ccccc2c1 |
| Storage condition | -20℃ |
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Name: Activation of human SIRT1 assessed as decrease in Km of enzyme for acetylated peptide...
Source: ChEMBL
Target: NAD-dependent protein deacetylase sirtuin-1
External Id: CHEMBL930181
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Name: Activation of SIRT1 in human U2OS cells assessed as decrease in deacetylation level a...
Source: ChEMBL
Target: NAD-dependent protein deacetylase sirtuin-1
External Id: CHEMBL933821
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Name: Activation of human SIRT1 expressed in Escherichia coli BL21 by mass spectrometry ass...
Source: ChEMBL
Target: NAD-dependent protein deacetylase sirtuin-1
External Id: CHEMBL933817
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