TZ9
Modify Date: 2024-01-14 11:45:13
TZ9 structure
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Common Name | TZ9 | ||
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| CAS Number | 1002789-86-7 | Molecular Weight | 366.331 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 675.9±65.0 °C at 760 mmHg | |
| Molecular Formula | C17H14N6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 362.6±34.3 °C | |
Use of TZ9TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM.IC50 value: 6 uM [1]Target: Rad6 inhibitorThe bulk of MDA-MB-231 cells treated with 10 μmol/L or more SMI #9 displayed a round morphology compared with controls and less than 5 μmol/L doses of SMI #9. Simultaneous comparison of SMIs #8 and 9 confirmed SMI #9 inhibits Matrigel-induced migration of MDA-MB-231 cells in a dose-dependent manner compared with SMI #8. 5 μmol/L SMI #9 treatment triggered morphologic changes consistent with apoptosis in a time-dependent manner. 5 μmol/L SMI #9 treatment of MDA-MB-231 cells for 24 hours increased the proportion of G2–M-arrested cells by 2-fold and was accompanied by a proportional decrease in S-phase cells. SMIs #8 or 9 treatments dramatically reduced β-catenin staining as visualized by reduced merged Rad6/β-catenin yellow fluorescence. |
| Name | (4-Amino-6-anilino-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate |
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| Synonym | More Synonyms |
| Description | TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM.IC50 value: 6 uM [1]Target: Rad6 inhibitorThe bulk of MDA-MB-231 cells treated with 10 μmol/L or more SMI #9 displayed a round morphology compared with controls and less than 5 μmol/L doses of SMI #9. Simultaneous comparison of SMIs #8 and 9 confirmed SMI #9 inhibits Matrigel-induced migration of MDA-MB-231 cells in a dose-dependent manner compared with SMI #8. 5 μmol/L SMI #9 treatment triggered morphologic changes consistent with apoptosis in a time-dependent manner. 5 μmol/L SMI #9 treatment of MDA-MB-231 cells for 24 hours increased the proportion of G2–M-arrested cells by 2-fold and was accompanied by a proportional decrease in S-phase cells. SMIs #8 or 9 treatments dramatically reduced β-catenin staining as visualized by reduced merged Rad6/β-catenin yellow fluorescence. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 675.9±65.0 °C at 760 mmHg |
| Molecular Formula | C17H14N6O4 |
| Molecular Weight | 366.331 |
| Flash Point | 362.6±34.3 °C |
| Exact Mass | 366.107666 |
| LogP | 1.75 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.711 |
| Storage condition | 2-8℃ |
| (4-Amino-6-anilino-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate |
| 1,3,5-Triazine-2-methanol, 4-amino-6-(phenylamino)-, 4-nitrobenzoate (ester) |
| TZ9 |