TZ9

• 常用名: TZ9
• 英文名: TZ9
• CAS号: 1002789-86-7
• 分子量: 366.331
• 密度: 1.5±0.1 g/cm3
• 沸点: 675.9±65.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄N₆O₄
• 熔点: N/A
• 闪点: 362.6±34.3 °C

TZ9用途

TZ9是泛素结合酶(E2 enzyme)Rad6新型抑制剂,抑制MDA-MB-231细胞增殖的IC50值约为6uM。

TZ9名称

• 中文名: TZ9
• 英文名: (4-Amino-6-anilino-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate

TZ9生物活性

• 描述: TZ9是泛素结合酶(E2 enzyme)Rad6新型抑制剂,抑制MDA-MB-231细胞增殖的IC50值约为6uM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> E1/E2/E3酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Sanders MA, et al. Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization. Mol Cancer Ther. 2013 Apr;12(4):373-83.

TZ9物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 675.9±65.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄N₆O₄
• 分子量: 366.331
• 闪点: 362.6±34.3 °C
• 精确质量: 366.107666
• LogP: 1.75
• InChIKey: RRRDZFQRNJTKHL-UHFFFAOYSA-N
• SMILES: Nc1nc(COC(=O)c2ccc([N+](=O)[O-])cc2)nc(Nc2ccccc2)n1
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.711
• 储存条件: 2-8℃

TZ9靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

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TZ9英文别名

• (4-Amino-6-anilino-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate
• 1,3,5-Triazine-2-methanol, 4-amino-6-(phenylamino)-, 4-nitrobenzoate (ester)
• TZ9