c-Kit-IN-5-1

Modify Date: 2024-01-08 08:42:53

c-Kit-IN-5-1 structure	Common Name	c-Kit-IN-5-1
	CAS Number	1003311-62-3	Molecular Weight	395.413
	Density	1.4±0.1 g/cm3	Boiling Point	720.7±70.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₁₇N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	389.7±35.7 °C

Use of c-Kit-IN-5-1

c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1].

Name	3-(2-Amino-6-quinazolinyl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]-2(1H)-pyridinone
Synonym	More Synonyms

Description	c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit
In Vitro	c-Kit-IN-5 (compound 25) shows more than 200-fold selectivity against KDR, p38, Lck, and Src (IC50=>5.0, 40, 7.8 , and >5.0 μM, respectively)[1].
In Vivo	c-Kit-IN-5 (compound 25) (1 mg/kg; i.v.) exhibits CL (0.46 L/h/kg) and Vdss (1.59 L/kg) in rats[1]. c-Kit-IN-5 (10 mg/kg; p.o.) exhibits AUC0-t(9860 ng•h/mL) Cmax(1230 ng/mL), T1/2 (2.6 h), and F (39%) in rats[1].
References	[1]. Hu E, et, al. Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit. J Med Chem. 2008 Jun 12;51(11):3065-8.

Density	1.4±0.1 g/cm3
Boiling Point	720.7±70.0 °C at 760 mmHg
Molecular Formula	C₂₃H₁₇N₅O₂
Molecular Weight	395.413
Flash Point	389.7±35.7 °C
Exact Mass	395.138214
LogP	2.78
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.709
Storage condition	-20°C

Hazard Codes	Xn

2(1H)-Pyridinone, 3-(2-amino-6-quinazolinyl)-4-methyl-1-[4-(2-oxazolyl)phenyl]-

3-(2-Amino-6-quinazolinyl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]-2(1H)-pyridinone

AMG-25

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AMG25
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Amg-25
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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