ISPA-28

更新时间：2025-08-25 17:08:17

ISPA-28结构式	常用名	ISPA-28	英文名	ISPA-28
	CAS号	1006335-39-2	分子量	408.454
	密度	1.4±0.1 g/cm3	沸点	N/A
	分子式	C₂₁H₂₄N₆O₃	熔点	N/A
	MSDS	美版	闪点	N/A

ISPA-28用途

ISPA-28 是特异性的疟原虫表面阴离子通道 (PSAC) 拮抗剂。ISPA-28 直接可逆的与CLAG3 结合。

英文名	N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide
英文别名	更多

描述	ISPA-28 是特异性的疟原虫表面阴离子通道 (PSAC) 拮抗剂。ISPA-28 直接可逆的与CLAG3 结合。
相关类别	研究领域 >> 感染
体外研究	ISPA-28仅作为Dd2通道的抑制剂有效(Dd2和HB3通道的K0.5值分别为56 nM和43μM)[2]。
参考文献	[1]. Sanjay A Desai, et al. Ion and Nutrient Uptake by Malaria Parasite-Infected Erythrocytes. [2]. Wang Nguitragool, et al. Proteolysis at a Specific Extracellular Residue Implicates Integral Membrane CLAG3 in Malaria Parasite Nutrient Channels.

密度	1.4±0.1 g/cm3
分子式	C₂₁H₂₄N₆O₃
分子量	408.454
精确质量	408.190979
LogP	0.18
InChIKey	YMLINDVVJXDIRW-UHFFFAOYSA-N
SMILES	CCn1cc(C2=NOC(C(=O)Nc3c(C)n(C)n(-c4ccccc4)c3=O)C2)c(C)n1
折射率	1.672

危险品运输编码	NONH for all modes of transport

An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptake.

J. Biol. Chem. 288(27) , 19429-40, (2013)

Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In Plasmodium falciparum, resistance is known to arise through genome-level chang...

Malaria parasite mutants with altered erythrocyte permeability: a new drug resistance mechanism and important molecular tool.

Future Microbiol. 5(1) , 81-97, (2010)

Erythrocytes infected with plasmodia, including those that cause human malaria, have increased permeability to a diverse collection of organic and inorganic solutes. While these increases have been kn...

5-Isoxazolecarboxamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-

N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide

MFCD08106635