cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)

Modify Date: 2025-08-25 18:14:17

cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat) structure	Common Name	cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)
	CAS Number	100853-58-5	Molecular Weight	1969.17000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₄H₁₃₇N₂₉O₂₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of cAMP-Dependent Protein Kinase Inhibitor-α (5-22) amide (human, mouse, rabbit, rat)

PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors[1][2].

Name	h-thr-thr-tyr-ala-asp-phe-ile-ala-ser-gly-arg-thr-gly-arg-arg-asn-ala-ile-nh2
Synonym	More Synonyms

Description	PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Neurological Disease
In Vitro	PKI(5-22)amide (1 μM; 1 min) fails to block CRF1 receptor (100 nM; 30 min) desensitization in Y-79 cells permeabilized with Streptolysin O (HY-135416)[1].
References	[1]. Dautzenberg FM, et al. GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R935-46. [2]. Reed J, et al. Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J. 1989 Dec 1;264(2):371-80.

Molecular Formula	C₈₄H₁₃₇N₂₉O₂₆
Molecular Weight	1969.17000
Exact Mass	1968.03000
PSA	931.05000

PKI (5-22),AMIDE

CAMP-DEPENDENT PROTEIN KINASE INHIBITOR (5-22) AMIDE

PKI-a (5-22) aMide (huMan,Mouse,rabbit,rat),Wiptide

cAMP-Dependent Protein Kinase Inhibitor (5-22),amide,Wiptide

WIPTIDE

PROTEIN KINASE A INHIBITOR (5-22) AMIDE

TTYADFIASGRTGRRNAI-NH2

CAMP DEPENDENT PK INHIBITOR (5-22) AMIDE

PKA INHIBITOR (5-22) AMIDE

THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2

THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-HIS-ASP: TTYADFIASGRTGRRNAIHD

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PKI(5-22)amide
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

GL Biochem (Shanghai) Ltd.
China
Product Name: cAMP-Dependent Protein Kinase Inhibitor (5-22), amide, Wiptide
Price: ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

DC Chemicals Limited
China
Product Name: PKI(5-22)amide
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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