HZ-1157

Modify Date: 2024-01-09 07:47:44

HZ-1157 structure	Common Name	HZ-1157
	CAS Number	1009734-33-1	Molecular Weight	232.282
	Density	1.2±0.1 g/cm3	Boiling Point	471.6±53.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₆N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	239.0±30.9 °C

Use of HZ-1157

HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].

Name	5-(tert-butoxy)quinazoline-2,4-diamine
Synonym	More Synonyms

Description	HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease Research Areas >> Inflammation/Immunology
Target	IC50: 1.0 μmol/L (HCV NS3/4A protease)[2].
In Vitro	HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others[1][2]. Cell Viability Assay[2]. Cell Line: HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others. Concentration: 0-10 μmol/L. Incubation Time: 72 h. Result: Inhibited HCV infection in vitro with an IC50 of 0.82 μmol/L.
References	[1]. Ye Yu, et al. Discovering Novel anti-HCV Compounds With Inhibitory Activities Toward HCV NS3/4A Protease. Acta Pharmacol Sin. 2014 Aug;35(8):1074-81. [2]. Bo Chao, et al. Discovery and Optimization of 2,4-diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors. J Med Chem . 2012 Apr 12;55(7):3135-43.

Density	1.2±0.1 g/cm3
Boiling Point	471.6±53.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₆N₄O
Molecular Weight	232.282
Flash Point	239.0±30.9 °C
Exact Mass	232.132416
PSA	87.05000
LogP	2.10
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.658
Storage condition	-20℃

2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-

5-tert-butoxy-2,4-diaminoquinazoline

5-tert-butoxyquinazoline-2,4-diamine

HZ-1157

5-[(2-Methyl-2-propanyl)oxy]-2,4-quinazolinediamine

DC Chemicals Limited
China
Product Name: HZ-1157
Price: $500.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-tert-butoxyquinazoline-2,4-diamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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