Metronidazole acetic acid

Modify Date: 2025-08-26 19:17:51

Metronidazole acetic acid Structure
Metronidazole acetic acid structure
Common Name Metronidazole acetic acid
CAS Number 1010-93-1 Molecular Weight 185.13700
Density 1.6g/cm3 Boiling Point 475.9ºC at 760mmHg
Molecular Formula C6H7N3O4 Melting Point N/A
MSDS Chinese USA Flash Point 241.6ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Metronidazole acetic acid


Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria. Metronidazole is a nitroimidazole antibiotic, amebicide, and antiprotozoal agent used particularly for anaerobic bacteria and protozoa[1][2][3].

 Names

Name 2-(2-methyl-5-nitroimidazol-1-yl)acetic acid
Synonym More Synonyms

 Metronidazole acetic acid Biological Activity

Description Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria. Metronidazole is a nitroimidazole antibiotic, amebicide, and antiprotozoal agent used particularly for anaerobic bacteria and protozoa[1][2][3].
Related Catalog
References

[1]. M Chacko, et al. Studies on the Possible Mutagenic Action of Metronidazole. Indian J Exp Biol. 1987 Apr;25(4):240-3.

[2]. M D Mudry, et al. Mutagenic Bioassay of Certain Pharmacological Drugs: III. Metronidazole (MTZ). Mutat Res. 1994 Mar 1;305(2):127-32.

[3]. In Schaechter, M.; Engleberg, N. C.; DiRita, V. J. et al. Schaechter's Mechanisms of Microbial Disease. Hagerstown, MD: Lippincott Williams & Wilkins. p. 28.

 Chemical & Physical Properties

Density 1.6g/cm3
Boiling Point 475.9ºC at 760mmHg
Molecular Formula C6H7N3O4
Molecular Weight 185.13700
Flash Point 241.6ºC
Exact Mass 185.04400
PSA 100.94000
LogP 0.70750
Vapour Pressure 7.28E-10mmHg at 25°C
Index of Refraction 1.646

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36
Safety Phrases 26
RIDADR NONH for all modes of transport
HS Code 2933290090

 Synthetic Route

~62%

Metronidazole acetic acid Structure

Metronidazole a...

CAS#:1010-93-1

Literature: Journal of Heterocyclic Chemistry, , vol. 45, # 3 p. 921 - 925

~13%

Metronidazole acetic acid Structure

Metronidazole a...

CAS#:1010-93-1

Literature: WO2014/7650 A1, ; Page/Page column 54; 55 ;

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Metronidazole acetic acid Structure

Metronidazole a...

CAS#:1010-93-1

Literature: European Journal of Medicinal Chemistry, , vol. 45, # 2 p. 661 - 666

 Customs

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles6

More Articles
Optimized liquid-chromatographic determination of metronidazole and its metabolites in plasma.

Clin. Chem. 30(5) , 784-7, (1984)

Metronidazole and its known metabolites in plasma can be rapidly separated by a "high-pressure" liquid-chromatographic method that can also be adapted for rapid determination of tinidazole. Samples de...

Steady-state pharmacokinetics of metronidazole in Crohn's disease.

Biopharm. Drug Dispos. 8(3) , 249-59, (1987)

The pharmacokinetics of metronidazole (MTZ) were studied in six Crohn's disease patients after multiple oral daily doses of 250, 500, 750, and 1000 mg day-1. Pharmacokinetic indices were found to be i...

Relative susceptibilities of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to Metronidazole and its two major metabolites.

Sex. Transm. Dis. 7(4) , 157-60, (1980)

The susceptibilities of strains of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to metronidazole and its principal oxidative metabolites (1-[2-hydroxy...

 Synonyms

2-Methyl-5-nitro-1H-imidazole-1-acetic acid
1-Carboxymethyl-2-methyl-5-nitro-imidazol
2-methyl-5-nitroimidazole-1-acetic acid
Metronidazole acetic acid
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