PSI-7409
Modify Date: 2024-01-09 15:40:04
PSI-7409 structure
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Common Name | PSI-7409 | ||
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| CAS Number | 1015073-42-3 | Molecular Weight | 500.159 | |
| Density | 2.0±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H16FN2O14P3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PSI-7409PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. |
| Name | 2'-deoxy-2'-α-fluoro-2'-β-C-methyl-U-TP |
|---|---|
| Synonym | More Synonyms |
| Description | PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. |
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| Related Catalog | |
| In Vitro | PSI-7409 inhibits the enzymatic activities of these NS5BΔ21 polymerases in a dose-dependent manner. The IC50s for PSI-7409 against GT 1b, 2a, 3a, and 4a NS5B polymerases are 1.6 μM, 2.8 μM, 0.7 μM, and 2.6 μM, respectively. PSI-7409 is a weak inhibitor of DNA Pol α (IC50=550 μM). DNA Pol β and γ are not inhibited by 1 mM PSI-7409. A significant amount of RNA product is made in the presence of 500 μM PSI-7409, about 85%[1]. In clone A cells, the levels of PSI-7409 gradually increases to a maximum concentration of about 25 μm over a period of 48 h. PSI-7409 forms at a much faster rate in primary human hepatocytes, achieving a maximum intracellular concentration of ∼100 μM at 4 h and remains at that concentration for 48 h[2]. |
| References |
[2]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. |
| Density | 2.0±0.1 g/cm3 |
|---|---|
| Molecular Formula | C10H16FN2O14P3 |
| Molecular Weight | 500.159 |
| Exact Mass | 499.979828 |
| PSA | 273.57000 |
| LogP | -4.81 |
| Index of Refraction | 1.601 |
| Storage condition | 2-8℃ |
| 2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine triphosphate |
| β-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate |
| Uridine, 2'-deoxy-2'-fluoro-2'-methyl-, 5'-(tetrahydrogen triphosphate) |
| 2'-Deoxy-2'-fluoro-2'-methyluridine 5'-(tetrahydrogen triphosphate) |
| PSI7409 |
| PSI-7409 |