Hydroxyzine (pamoate)
Hydroxyzine (pamoate) structure
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Common Name | Hydroxyzine (pamoate) | ||
|---|---|---|---|---|
| CAS Number | 10246-75-0 | Molecular Weight | 763.274 | |
| Density | 1.182g/cm3 | Boiling Point | 499.2ºC at 760mmHg | |
| Molecular Formula | C44H43ClN2O8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 255.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Hydroxyzine (pamoate)Hydroxyzine pamoate is a histamine H1-receptor antagonist.Target: Histamine H1-ReceptorHydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min [1]. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE) [2]. Hydroxyzine (500 M) significantly increases transport of etoposide to the serosal site in the jejunal everted sacs. Hydroxyzine significantly reduces the efflux and approximately 2.4 ug/mL of etoposide in the jejunum and ileum. Hydroxyzine (0.2 μg/mL) significantly enhances the efflux of RH123 to the lumen [3].Hydroxyzine (500 μM) significantly decreases the steady-state etoposide concentration 2-fold, where the steady-state concentration reached about 0.055 μM/mL in Sprague-Dawley rats [3]. Hydroxyzine (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats [4]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | hydroxyzine pamoate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Hydroxyzine pamoate is a histamine H1-receptor antagonist.Target: Histamine H1-ReceptorHydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min [1]. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE) [2]. Hydroxyzine (500 M) significantly increases transport of etoposide to the serosal site in the jejunal everted sacs. Hydroxyzine significantly reduces the efflux and approximately 2.4 ug/mL of etoposide in the jejunum and ileum. Hydroxyzine (0.2 μg/mL) significantly enhances the efflux of RH123 to the lumen [3].Hydroxyzine (500 μM) significantly decreases the steady-state etoposide concentration 2-fold, where the steady-state concentration reached about 0.055 μM/mL in Sprague-Dawley rats [3]. Hydroxyzine (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats [4]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.182g/cm3 |
|---|---|
| Boiling Point | 499.2ºC at 760mmHg |
| Molecular Formula | C44H43ClN2O8 |
| Molecular Weight | 763.274 |
| Flash Point | 255.7ºC |
| Exact Mass | 762.270813 |
| PSA | 151.00000 |
| LogP | 7.32310 |
| Vapour Pressure | 2.13E-17mmHg at 25°C |
| InChIKey | ASDOKGIIKXGMNB-UHFFFAOYSA-N |
| SMILES | O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O.OCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1 |
| Storage condition | -20℃ |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Microencapsulation of hydroxyzine HCl by thermal phase separation: in vitro release enhancement and in vivo pharmacodynamic evaluation.
Pharm. Dev. Technol. 18(1) , 196-209, (2013) The systemic effect of hydroxyzine hydrochloride following its oral administration or topical application is associated with non compliant anticholinergic effect. Subsequently, the present study aims ... |
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Worsening of contact dermatitis by oral hydroxyzine: a case report.
Dermatol. Online J. 19(2) , 4, (2013) Hydroxyzine is commonly used to treat pruritic skin lesions. Although rare, hydroxyzine can sometimes be linked to worsening dermatitis in patients who have sensitivities to phenothiazines and/or ethy... |
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Acute generalized exanthematous pustulosis associated with 2 common medications: hydroxyzine and benzocaine.
J. Am. Acad. Dermatol. 71(4) , e147-9, (2014)
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This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL4296184
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Name: Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL4296186
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Name: Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL4296185
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Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
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Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Paxistil {Pamoate} |
| Equipose {Pamoate} |
| 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) - 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)ethanol (1:1) |
| Paxisitil |
| 4,4'-methanediylbis(3-hydroxynaphthalene-2-carboxylic acid) - 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol (1:1) |
| Bobsule |
| Atarax P |
| Hydroxyzine pamoate salt |
| 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid,2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol |
| hydroxyzine pamoate |
| acide 4,4'-méthanediylbis(3-hydroxynaphtalène-2-carboxylique) - 2-(2-{4-[(4-chlorophényl)(phényl)méthyl]pipérazin-1-yl}éthoxy)éthanol (1:1) |
| 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol (1:1) |
| Hydroxyzyne pamoate |
| 4,4'-Methandiylbis(3-hydroxynaphthalen-2-carbonsäure)--2-(2-{4-[(4-chlorphenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol(1:1) |
| EINECS 233-582-1 |
| Hydroxyzine embonate |
| Hydroxyzine (pamoate) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of hydroxyzine pamoate? |
| A: Molecular formula of hydroxyzine pamoate is C44H43ClN2O8. |
| Q: What is the English name of hydroxyzine pamoate? |
| A: The English name of hydroxyzine pamoate is hydroxyzine pamoate. |
| Q: What is the safety information for hydroxyzine pamoate? |
| A: Safety information for hydroxyzine pamoate: 36. |
| Q: What is the CAS number of hydroxyzine pamoate? |
| A: CAS number of hydroxyzine pamoate is 10246-75-0. |
| Q: What is the boiling point of hydroxyzine pamoate? |
| A: Boiling point of hydroxyzine pamoate is 499.2ºC at 760mmHg. |
| Q: What is the LogP of hydroxyzine pamoate? |
| A: LogP of hydroxyzine pamoate is 7.32310. |
| Q: What is the polar surface area (PSA) of hydroxyzine pamoate? |
| A: Polar surface area (PSA) of hydroxyzine pamoate is 151.00000. |
| Q: What is the InChIKey of hydroxyzine pamoate? |
| A: InChIKey of hydroxyzine pamoate is ASDOKGIIKXGMNB-UHFFFAOYSA-N. |
| Q: What is the molecular weight of hydroxyzine pamoate? |
| A: Molecular weight of hydroxyzine pamoate is 763.274. |
| Q: What are the storage conditions for hydroxyzine pamoate? |
| A: Storage conditions for hydroxyzine pamoate: -20℃. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |