trans-Isoferulic acid-d3

Modify Date: 2024-03-26 09:27:59

trans-Isoferulic acid-d3 structure	Common Name	trans-Isoferulic acid-d3
	CAS Number	1028203-97-5	Molecular Weight	197.20200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₇D₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of trans-Isoferulic acid-d3

trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[3].

Name	3-Hydroxy-4-methoxycinnamic Acid-d3 (Isoferulic Acid-d3)
Synonym	More Synonyms

Description	trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Kai-Hui Sun, et al. A new indole-type alkaloid from the roots of <i>Clematis florida var. plena</i>. Nat Prod Res. 2019 Oct;33(20):2925-2931. [3]. Matharage Gayani Dilshara, et al. Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1. Int Immunopharmacol. 2014 Jan18(1):203-11.

Molecular Formula	C₁₀H₇D₃O₄
Molecular Weight	197.20200
Exact Mass	197.07700
PSA	66.76000
LogP	1.49860

(E)-3-[3-hydroxy-4-(trideuteriomethoxy)phenyl]prop-2-enoic acid

trans-Isoferulic acid-d3

Use of trans-Isoferulic acid-d3

Names

trans-Isoferulic acid-d3 Biological Activity

Chemical & Physical Properties

Synonyms