Isoferulic acid

Modify Date: 2024-01-02 11:55:14

Isoferulic acid structure	Common Name	Isoferulic acid
	CAS Number	25522-33-2	Molecular Weight	194.184
	Density	1.3±0.1 g/cm3	Boiling Point	410.2±35.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₀O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	167.6±19.4 °C

Use of Isoferulic acid

trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[1].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[2].

Name	trans-Isoferulic acid
Synonym	More Synonyms

Description	trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[1].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	Human Endogenous Metabolite
References	[1]. Kai-Hui Sun, et al. A new indole-type alkaloid from the roots of Clematis florida var. plena. Nat Prod Res. 2019 Oct;33(20):2925-2931. [2]. Matharage Gayani Dilshara, et al. Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1. Int Immunopharmacol. 2014 Jan;18(1):203-11.

Density	1.3±0.1 g/cm3
Boiling Point	410.2±35.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₀O₄
Molecular Weight	194.184
Flash Point	167.6±19.4 °C
Exact Mass	194.057907
PSA	66.76000
LogP	1.56
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.627
Storage condition	2-8°C

Isoferulic acid MSDS(Chinese)

Hazard Codes	Xi
RIDADR	NONH for all modes of transport

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Isoferulic acid

EINECS 247-071-6