Nitisinone

Modify Date: 2024-01-02 17:35:44

Nitisinone Structure
Nitisinone structure
 Common Name Nitisinone
CAS Number 104206-65-7 Molecular Weight 329.228
Density 1.5±0.1 g/cm3 Boiling Point 486.2±45.0 °C at 760 mmHg
Molecular Formula C14H10F3NO5 Melting Point 129-131°C
MSDS Chinese USA Flash Point 247.9±28.7 °C

 Use of Nitisinone


Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.Target: 4-Hydroxyphenylpyruvate DioxygenaseNitisinone is a drug used to slow the effects of hereditary tyrosinemia type 1. Nitisinone reduced urinary HGA levels from an average of 4.0 +/- 1.8 (SD) g/day to 0.2 +/- 0.2 g/day ( P < .001). Low-dose nitisinone effectively reduced urinary HGA levels in patients with alkaptonuria. Future long-term clinical trials are planned to determine the benefits of nitisinone in preventing joint deterioration and providing pain relief, and its long-term side effects [1]. Nitisinone can prevent the development of liver disease and significantly reduce the risk of developing hepatocellular carcinoma; however, vigorous surveillance for the development of HCC needs to be continued lifelong [2].

 Names

Name nitisinone
Synonym More Synonyms

 Nitisinone Biological Activity

Description Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.Target: 4-Hydroxyphenylpyruvate DioxygenaseNitisinone is a drug used to slow the effects of hereditary tyrosinemia type 1. Nitisinone reduced urinary HGA levels from an average of 4.0 +/- 1.8 (SD) g/day to 0.2 +/- 0.2 g/day ( P < .001). Low-dose nitisinone effectively reduced urinary HGA levels in patients with alkaptonuria. Future long-term clinical trials are planned to determine the benefits of nitisinone in preventing joint deterioration and providing pain relief, and its long-term side effects [1]. Nitisinone can prevent the development of liver disease and significantly reduce the risk of developing hepatocellular carcinoma; however, vigorous surveillance for the development of HCC needs to be continued lifelong [2].
Related Catalog
References

[1]. Suwannarat, P., et al., Use of nitisinone in patients with alkaptonuria. Metabolism, 2005. 54(6): p. 719-28.

[2]. Santra, S. and U. Baumann, Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother, 2008. 9(7): p. 1229-36.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 486.2±45.0 °C at 760 mmHg
Melting Point 129-131°C
Molecular Formula C14H10F3NO5
Molecular Weight 329.228
Flash Point 247.9±28.7 °C
Exact Mass 329.051117
PSA 97.03000
LogP 1.37
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.535
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GV0766666
CHEMICAL NAME :
1,3-Cyclohexanedione, 2-(2-nitro-4-trifluorobenzoyl)-
CAS REGISTRY NUMBER :
104206-65-7
LAST UPDATED :
199806
DATA ITEMS CITED :
1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4200 ug/kg/6W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage Blood - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 141,439,1996

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport
HS Code 2914700090

 Customs

HS Code 2914700090
Summary HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

 Articles29

More Articles
Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells.

PLoS Biol. 9(7) , e1001099, (2011)

Using the murine model of tyrosinemia type 1 (fumarylacetoacetate hydrolase [FAH] deficiency; FAH⁻/⁻ mice) as a paradigm for orphan disorders, such as hereditary metabolic liver diseases, we evaluated...
Serum markers in alkaptonuria: simultaneous analysis of homogentisic acid, tyrosine and nitisinone by liquid chromatography tandem mass spectrometry.

Ann. Clin. Biochem. 52 , 597-605, (2015)

Alkaptonuria is a rare debilitating autosomal recessive disorder of tyrosine metabolism, where deficiency of homogentisate 1,2-dioxygenase results in increased homogentisic acid. Homogentisic acid is ...
A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.

BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)

 Synonyms

nitisinonum
2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione
2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione
2-(2-nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione
Orfadin
Nitisinone [INN]
nitisinona
Orfadin (TN)
1,3-Cyclohexanedione, 2-[2-nitro-4-(trifluoromethyl)benzoyl]-
Nitisone
2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione
2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
Nitisinone
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Related Compounds: More...
Nitisinone-13C6
1246815-63-3
Chemsrc provides Nitisinone(CAS#:104206-65-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Nitisinone are included as well.>> amp version: Nitisinone

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