Famciclovir
Modify Date: 2024-01-02 16:01:07
Famciclovir structure
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Common Name | Famciclovir | ||
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| CAS Number | 104227-87-4 | Molecular Weight | 321.332 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 550.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C14H19N5O4 | Melting Point | 102-104°C | |
| MSDS | Chinese USA | Flash Point | 286.6±32.9 °C | |
Use of FamciclovirFamciclovir(BRL 42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.IC50 Value: Refer to penciclovirTarget: HSVFamciclovir is the diacetyl 6-deoxy analog of the active antiviral compound penciclovir with potential use in the treatment of infections caused by the herpes family of viruses [1]. Famciclovir, a synthetic acyclic guanine derivative, is a prodrug which, after oral administration, is rapidly metabolised to the highly bioavailable antiviral compound penciclovir [2].in vitro: Famciclovir induced rapid, dose-dependent suppression of viral replication and reduction in alanine aminotransferase (ALT), with greatest efficacy in the 500-mg tid treatment group. HBV DNA reduction was maintained throughout the treatment period. ALT also steadily declined during the treatment period [3]. in vivo: In rat, following dosing at 40 mg/kg, famciclovir was rapidly and extensively metabolized to the active antiviral compound penciclovir, which reached peak concentrations in the plasma (mean 3.5 micrograms/ml) at 0.5 h [4]. Necrotic hepatitis was significantly (p < 0.01) reduced by treatment with FCV, VACV and ACV at a dose of 50 mg/kg per day divided into 3 doses. No significant effect was achieved with BVDU at 200 mg/kg per day. Treatment with FCV at 50 mg/kg per day, ACV at 100 mg/kg per day, and VACV at 200 mg/kg per day significantly (p < 0.001) decreased mortality in mice [5].Clinical trial: Famciclovir Pediatric Formulation In Children 1 to 12 Years Of Age With Herpes Simplex Infection. Phage3 |
| Name | famciclovir |
|---|---|
| Synonym | More Synonyms |
| Description | Famciclovir(BRL 42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.IC50 Value: Refer to penciclovirTarget: HSVFamciclovir is the diacetyl 6-deoxy analog of the active antiviral compound penciclovir with potential use in the treatment of infections caused by the herpes family of viruses [1]. Famciclovir, a synthetic acyclic guanine derivative, is a prodrug which, after oral administration, is rapidly metabolised to the highly bioavailable antiviral compound penciclovir [2].in vitro: Famciclovir induced rapid, dose-dependent suppression of viral replication and reduction in alanine aminotransferase (ALT), with greatest efficacy in the 500-mg tid treatment group. HBV DNA reduction was maintained throughout the treatment period. ALT also steadily declined during the treatment period [3]. in vivo: In rat, following dosing at 40 mg/kg, famciclovir was rapidly and extensively metabolized to the active antiviral compound penciclovir, which reached peak concentrations in the plasma (mean 3.5 micrograms/ml) at 0.5 h [4]. Necrotic hepatitis was significantly (p < 0.01) reduced by treatment with FCV, VACV and ACV at a dose of 50 mg/kg per day divided into 3 doses. No significant effect was achieved with BVDU at 200 mg/kg per day. Treatment with FCV at 50 mg/kg per day, ACV at 100 mg/kg per day, and VACV at 200 mg/kg per day significantly (p < 0.001) decreased mortality in mice [5].Clinical trial: Famciclovir Pediatric Formulation In Children 1 to 12 Years Of Age With Herpes Simplex Infection. Phage3 |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 550.2±60.0 °C at 760 mmHg |
| Melting Point | 102-104°C |
| Molecular Formula | C14H19N5O4 |
| Molecular Weight | 321.332 |
| Flash Point | 286.6±32.9 °C |
| Exact Mass | 321.143707 |
| PSA | 122.22000 |
| LogP | -0.67 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.628 |
| Storage condition | -20°C Freezer |
| Hazard Codes | T: Toxic; |
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| Risk Phrases | R20/21/22 |
| Safety Phrases | 36/37/39-45-53 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | UB8070000 |
| HS Code | 2942000000 |
| Precursor 9 | |
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| DownStream 3 | |
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CAS#:104227-90-9| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Dissolution testing and potentiometric determination of famciclovir in pure, dosage forms and biological fluids.
Bioelectrochemistry 89 , 26-33, (2013) The performance characteristics of two new plastic membrane ion selective electrodes (ISEs) used for the determination of famciclovir (Fcv) based on the ion associate of Fcv with phosphotungstic acid ... |
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Pediatric herpes simplex of the anterior segment: characteristics, treatment, and outcomes.
Ophthalmology 119(10) , 2003-8, (2012) To describe the clinical characteristics, treatment, and outcomes of herpes simplex virus (HSV) infections of the cornea and adnexae to raise awareness and to improve management of this important eye ... |
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Estimates of the pharmacokinetics of famciclovir and its active metabolite penciclovir in young Asian elephants (Elephas maximus).
Am. J. Vet. Res. 73(12) , 1996-2000, (2012) To determine plasma pharmacokinetics of penciclovir following oral and rectal administration of famciclovir to young Asian elephants (Elephas maximus).6 healthy Asian elephants (5 females and 1 male),... |
| 2-(2-(2-Amino-9H-purin-9-yl)ethyl)propane-1,3-diyl diacetate |
| acétate de 2-[(acétyloxy)méthyl]-4-(2-amino-9H-purin-9-yl)butyle |
| 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester |
| 2-(Acetoxymethyl)-4-(2-amino-9H-purin-9-yl)butyl acetate |
| 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate |
| Famciclovir |
| Amciclovir |
| Famciclover |
| 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate (non-preferred name) |
| 2-[(Acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butylacetat |
| FaMtrex |
| Famvir |
| FaMciclovir API |
| famcyclovir |
| FCV |
| MFCD00866964 |
| 1,3-Propanediol, 2-[2-(2-amino-9H-purin-9-yl)ethyl]-, diacetate (ester) |
| 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate (Ester) |
| 9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine |
| FaMcivir |