Famciclovir

Modify Date: 2024-01-02 16:01:07

Famciclovir Structure
Famciclovir structure
 Common Name Famciclovir
CAS Number 104227-87-4 Molecular Weight 321.332
Density 1.4±0.1 g/cm3 Boiling Point 550.2±60.0 °C at 760 mmHg
Molecular Formula C14H19N5O4 Melting Point 102-104°C
MSDS Chinese USA Flash Point 286.6±32.9 °C

 Use of Famciclovir


Famciclovir(BRL 42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.IC50 Value: Refer to penciclovirTarget: HSVFamciclovir is the diacetyl 6-deoxy analog of the active antiviral compound penciclovir with potential use in the treatment of infections caused by the herpes family of viruses [1]. Famciclovir, a synthetic acyclic guanine derivative, is a prodrug which, after oral administration, is rapidly metabolised to the highly bioavailable antiviral compound penciclovir [2].in vitro: Famciclovir induced rapid, dose-dependent suppression of viral replication and reduction in alanine aminotransferase (ALT), with greatest efficacy in the 500-mg tid treatment group. HBV DNA reduction was maintained throughout the treatment period. ALT also steadily declined during the treatment period [3]. in vivo: In rat, following dosing at 40 mg/kg, famciclovir was rapidly and extensively metabolized to the active antiviral compound penciclovir, which reached peak concentrations in the plasma (mean 3.5 micrograms/ml) at 0.5 h [4]. Necrotic hepatitis was significantly (p < 0.01) reduced by treatment with FCV, VACV and ACV at a dose of 50 mg/kg per day divided into 3 doses. No significant effect was achieved with BVDU at 200 mg/kg per day. Treatment with FCV at 50 mg/kg per day, ACV at 100 mg/kg per day, and VACV at 200 mg/kg per day significantly (p < 0.001) decreased mortality in mice [5].Clinical trial: Famciclovir Pediatric Formulation In Children 1 to 12 Years Of Age With Herpes Simplex Infection. Phage3

 Names

Name famciclovir
Synonym More Synonyms

 Famciclovir Biological Activity

Description Famciclovir(BRL 42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.IC50 Value: Refer to penciclovirTarget: HSVFamciclovir is the diacetyl 6-deoxy analog of the active antiviral compound penciclovir with potential use in the treatment of infections caused by the herpes family of viruses [1]. Famciclovir, a synthetic acyclic guanine derivative, is a prodrug which, after oral administration, is rapidly metabolised to the highly bioavailable antiviral compound penciclovir [2].in vitro: Famciclovir induced rapid, dose-dependent suppression of viral replication and reduction in alanine aminotransferase (ALT), with greatest efficacy in the 500-mg tid treatment group. HBV DNA reduction was maintained throughout the treatment period. ALT also steadily declined during the treatment period [3]. in vivo: In rat, following dosing at 40 mg/kg, famciclovir was rapidly and extensively metabolized to the active antiviral compound penciclovir, which reached peak concentrations in the plasma (mean 3.5 micrograms/ml) at 0.5 h [4]. Necrotic hepatitis was significantly (p < 0.01) reduced by treatment with FCV, VACV and ACV at a dose of 50 mg/kg per day divided into 3 doses. No significant effect was achieved with BVDU at 200 mg/kg per day. Treatment with FCV at 50 mg/kg per day, ACV at 100 mg/kg per day, and VACV at 200 mg/kg per day significantly (p < 0.001) decreased mortality in mice [5].Clinical trial: Famciclovir Pediatric Formulation In Children 1 to 12 Years Of Age With Herpes Simplex Infection. Phage3
Related Catalog
References

[1]. Harrell AW, Wheeler SM, Pennick M, Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta-hydroxylation of testosterone in human liver microsomes. Drug Metab Dispos. 1993 Jan-Feb;21(1):18-23.

[2]. Perry CM, Wagstaff AJ. Famciclovir. A review of its pharmacological properties and therapeutic efficacy in herpesvirus infections. Drugs. 1995 Aug;50(2):396-415.

[3]. Trépo C, Jezek P, Atkinson G, Famciclovir in chronic hepatitis B: results of a dose-finding study. J Hepatol. 2000 Jun;32(6):1011-8.

[4]. Filer CW, Ramji JV, Allen GD, Metabolic and pharmacokinetic studies following oral administration of famciclovir to the rat and dog. Xenobiotica. 1995 May;25(5):477-90.

[5]. Wutzler P, Ulbricht A, F?rber I. Antiviral efficacies of famciclovir, valaciclovir, and brivudin in disseminated herpes simplex virus type 1 infection in mice. Intervirology. 1997;40(1):15-21.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 550.2±60.0 °C at 760 mmHg
Melting Point 102-104°C
Molecular Formula C14H19N5O4
Molecular Weight 321.332
Flash Point 286.6±32.9 °C
Exact Mass 321.143707
PSA 122.22000
LogP -0.67
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.628
Storage condition -20°C Freezer

 Safety Information

Hazard Codes T: Toxic;
Risk Phrases R20/21/22
Safety Phrases 36/37/39-45-53
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS UB8070000
HS Code 2942000000

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles49

More Articles
Dissolution testing and potentiometric determination of famciclovir in pure, dosage forms and biological fluids.

Bioelectrochemistry 89 , 26-33, (2013)

The performance characteristics of two new plastic membrane ion selective electrodes (ISEs) used for the determination of famciclovir (Fcv) based on the ion associate of Fcv with phosphotungstic acid ...
Pediatric herpes simplex of the anterior segment: characteristics, treatment, and outcomes.

Ophthalmology 119(10) , 2003-8, (2012)

To describe the clinical characteristics, treatment, and outcomes of herpes simplex virus (HSV) infections of the cornea and adnexae to raise awareness and to improve management of this important eye ...
Estimates of the pharmacokinetics of famciclovir and its active metabolite penciclovir in young Asian elephants (Elephas maximus).

Am. J. Vet. Res. 73(12) , 1996-2000, (2012)

To determine plasma pharmacokinetics of penciclovir following oral and rectal administration of famciclovir to young Asian elephants (Elephas maximus).6 healthy Asian elephants (5 females and 1 male),...

 Synonyms

2-(2-(2-Amino-9H-purin-9-yl)ethyl)propane-1,3-diyl diacetate
acétate de 2-[(acétyloxy)méthyl]-4-(2-amino-9H-purin-9-yl)butyle
2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester
2-(Acetoxymethyl)-4-(2-amino-9H-purin-9-yl)butyl acetate
2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate
Famciclovir
Amciclovir
Famciclover
2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate (non-preferred name)
2-[(Acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butylacetat
FaMtrex
Famvir
FaMciclovir API
famcyclovir
FCV
MFCD00866964
1,3-Propanediol, 2-[2-(2-amino-9H-purin-9-yl)ethyl]-, diacetate (ester)
2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate (Ester)
9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine
FaMcivir
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Related Compounds: More...
Famciclovir-d4
1020719-42-9
Desacetyl Famciclovir
104227-88-5
Famciclovir impurity 7
127205-22-5
Famciclovir Impurity 1
97845-60-8
Famciclovir Impurity 7
97845-72-2
Famciclovir Impurity 4
39809-25-1
Famciclovir Impurity 2
104227-86-3
Famciclovir Impurity 8
97845-80-2
.monohydroxy-famciclovir
120687-07-2
Chemsrc provides Famciclovir(CAS#:104227-87-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Famciclovir are included as well.>> amp version: Famciclovir

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