2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate

Modify Date: 2025-08-25 19:05:32

2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate Structure
2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate structure
Common Name 2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate
CAS Number 104777-03-9 Molecular Weight 325.34000
Density 1.363g/cm3 Boiling Point N/A
Molecular Formula C13H15N3O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate


Asobamast is a potent, orally active antiallergic agent that inhibits ige mediated passive pulmonary allergic responses in rats (ED50=4.7 mg/kg) and inhibits antigen-induced mediator release from sensitized guinea pig lung fragments[1].

 Names

Name 2-ethoxyethyl 2-[[4-(3-methyl-1,2-oxazol-5-yl)-1,3-thiazol-2-yl]amino]-2-oxoacetate
Synonym More Synonyms

  Biological Activity

Description Asobamast is a potent, orally active antiallergic agent that inhibits ige mediated passive pulmonary allergic responses in rats (ED50=4.7 mg/kg) and inhibits antigen-induced mediator release from sensitized guinea pig lung fragments[1].
Related Catalog
References

[1]. D Chiarino, et al. N-(4-Isoxazolylthiazol-2-yl)oxamic acid derivatives as potent orally active antianaphylactic agents. J Med Chem. 1991 Feb;34(2):600-5.   

 Chemical & Physical Properties

Density 1.363g/cm3
Molecular Formula C13H15N3O5S
Molecular Weight 325.34000
Exact Mass 325.07300
PSA 131.79000
LogP 1.69770
Index of Refraction 1.574
InChIKey IKYTUOHXXXPNOG-UHFFFAOYSA-N
SMILES CCOCCOC(=O)C(=O)Nc1nc(-c2cc(C)no2)cs1

 Safety Information

HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Asobamast
Acetic acid,2-[[4-(3-methyl-5-isoxazolyl)-2-thiazolyl]amino]-2-oxo-,2-ethoxyethyl ester
2-ethoxyethyl{[4-(3-methyl-1,2-oxazol-5-yl)-1,3-thiazol-2-yl]amino}(oxo)acetate
2-ethoxyethyl N-[4-(3-methyl-5-isoxazolyl)-2-thiazolyl]oxamate
Asobamastum [INN-Latin]
UNII-F0R68O7C4V
Asobamastum
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