Mometasone

Modify Date: 2026-06-30 19:33:15

Mometasone Structure
Mometasone structure
Common Name Mometasone
CAS Number 105102-22-5 Molecular Weight 427.4
Density 1.35g/cm3 Boiling Point 586.6ºC at 760mmHg
Molecular Formula C22H28Cl2O4 Melting Point 220ºC (decomposes)
MSDS N/A Flash Point 308.5ºC

 Use of Mometasone


Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis[1][2].

 Names

Name mometasone
Synonym More Synonyms

 Mometasone Biological Activity

Description Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis[1][2].
Related Catalog
In Vivo Mometasone (0.1-3 mg/kg; intranasally) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested of 3 mg/kg, and dose-dependently inhibits the allergen-induced increase in Penh in a mouse model of allergic lung inflammation[3].
References

[1]. Veien NK, et al. Long-term, intermittent treatment of chronic hand eczema with mometasone furoate. Br J Dermatol. 1999 May;140(5):882-6.

[2]. Lazarus SC, et al. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 May 23;380(21):2009-2019.

[3]. Wyss D, et al. Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation. Br J Pharmacol. 2007 Sep;152(1):83-90.

 Chemical & Physical Properties

Density 1.35g/cm3
Boiling Point 586.6ºC at 760mmHg
Melting Point 220ºC (decomposes)
Molecular Formula C22H28Cl2O4
Molecular Weight 427.4
Flash Point 308.5ºC
Exact Mass 426.1364648
PSA 93.81000
LogP 4.86920
Vapour Pressure 4.47E-18mmHg at 25°C
Index of Refraction 1.603
InChIKey QLIIKPVHVRXHRI-CXSFZGCWSA-N
SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)Cl)C

 Precursor & DownStream

Precursor  2

DownStream  0

 MometasoneBioassay

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Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909317
Name: Induction of mitochondrial dysfunction in Sprague-Dawley rat liver mitochondria asses...
Source: ChEMBL
Target: Liver
External Id: CHEMBL4011674
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909316
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909319
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909318
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909320
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909309
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909308
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909311
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909310
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 Synonyms

9a,21-dichloro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione
MFCD02683426
Pregna-1,4-diene-3,20-dione,9,21-dichloro-11,17-dihydroxy-16-methyl-,(11b,16a)-(9CI)
Mometasone
MOMETOSONE FUROATE
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