Palmatine hydrochloride

Modify Date: 2024-01-02 19:24:50

Palmatine hydrochloride Structure
Palmatine hydrochloride structure
Common Name Palmatine hydrochloride
CAS Number 10605-02-4 Molecular Weight 387.857
Density N/A Boiling Point N/A
Molecular Formula C21H22ClNO4 Melting Point 205 °C
MSDS N/A Flash Point N/A

 Use of Palmatine hydrochloride


Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties. IC50 value:Target:In vitro: Experimental set examined the influence of palmatine on osteoblast-like cells in vitro. In the culture supernatant of MC3T3-E1 cells, RANKL and OPG levels were significantly reduced by palmatine addition [1]. In vivo: The first experimentaI set was designed to histologically and biochemically examine mice randomly divided into four groups: sham-operated, OVX, and OVX-palmatine intake groups (1 mg/kg and 10 mg/kg). In palmatine-treated mice, RANKL and OPG expression decreased [1].

 Names

Name 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium,chloride
Synonym More Synonyms

 Palmatine hydrochloride Biological Activity

Description Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties. IC50 value:Target:In vitro: Experimental set examined the influence of palmatine on osteoblast-like cells in vitro. In the culture supernatant of MC3T3-E1 cells, RANKL and OPG levels were significantly reduced by palmatine addition [1]. In vivo: The first experimentaI set was designed to histologically and biochemically examine mice randomly divided into four groups: sham-operated, OVX, and OVX-palmatine intake groups (1 mg/kg and 10 mg/kg). In palmatine-treated mice, RANKL and OPG expression decreased [1].
Related Catalog
References

[1]. SHINTARO ISHIKAWA, et al. Influence of Palmatine on Bone Metabolism in Ovariectomized Mice and Cytokine Secretion of Osteoblasts.

[2]. Chen-Wen Xiao, er al. Antifungal activity of berberine hydrochloride and palmatine hydrochloride against Microsporum canis -induced dermatitis in rabbits and underlying mechanism. BMC Complement Altern Med. 2015; 15: 177.

 Chemical & Physical Properties

Melting Point 205 °C
Molecular Formula C21H22ClNO4
Molecular Weight 387.857
Exact Mass 387.123749
PSA 40.80000
LogP 0.38880
Vapour Pressure 6.6E-15mmHg at 25°C
Index of Refraction 1.624

 Safety Information

Risk Phrases 20/22-36/38
Safety Phrases 24/45
HS Code 2933990090

 Precursor & DownStream

Precursor  0

DownStream  2

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride (1:1)
Palmatine chloride
GNF-PF-4086
2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium chloride
Palmatine chloride,Palmatine hydrochloride
Palmatinehydrochloride
2,3,9,10-Tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium chloride
Prestwick_374
Palmatine (chloride)
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