MK6-83

Modify Date: 2024-01-09 17:39:18

MK6-83 structure	Common Name	MK6-83
	CAS Number	1062271-24-2	Molecular Weight	336.472
	Density	1.3±0.1 g/cm3	Boiling Point	502.6±60.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₂₀N₂O₂S₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	257.8±32.9 °C

Use of MK6-83

MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1].

Name	5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
Synonym	More Synonyms

Description	MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Metabolic Disease
In Vitro	MK6-83 2 ranging from 0.2 to 30 μM shows no signs of cytotoxicity[1]. MK6-83 appears to be significantly more efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells than on those isolated from TRPML1-/- cells[1]. Cell Viability Assay[1]. Cell Line: Lysosomes isolated from fibroblast cell lines derived from MLIV patients carrying either the F408D, the R403C or the V446L mutation[1]. Concentration: 0-10 μM. Incubation Time: 24 h. Result: Efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells. Had no significant effect on lysosomes isolated from TRPML1-/- fibroblasts.
References	[1]. Cheng-Chang Chen, et al. A Small Molecule Restores Function to TRPML1 Mutant Isoforms Responsible for Mucolipidosis Type IV. Nat Commun. 2014 Aug 14;5:4681.

Density	1.3±0.1 g/cm3
Boiling Point	502.6±60.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₀N₂O₂S₂
Molecular Weight	336.472
Flash Point	257.8±32.9 °C
Exact Mass	336.096619
LogP	3.40
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.633
Storage condition	-20°C

RIDADR	NONH for all modes of transport

2-Thiophenesulfonamide, 5-methyl-N-[2-(1-piperidinyl)phenyl]-

5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MK6-83
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: MK6-83
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: MK6-83
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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MK6-83 suppliers

Price: ￥750/5 mg

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