Desvenlafaxine-d10

Modify Date: 2024-01-09 19:58:00

Desvenlafaxine-d10 structure	Common Name	Desvenlafaxine-d10
	CAS Number	1062607-49-1	Molecular Weight	273.44
	Density	1.1±0.1 g/cm3	Boiling Point	403.8±25.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₅D₁₀NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	193.2±21.8 °C

Use of Desvenlafaxine-d10

Desvenlafaxine-d10 is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

Name	4-{2-(Dimethylamino)-1-[1-hydroxy(2H10)cyclohexyl]ethyl}phenol
Synonym	More Synonyms

Description	Desvenlafaxine-d10 is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Deecher, D.C., et al., Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther, 2006. 318(2): p. 657-65. [3]. Sopko, M.A., Jr., M.J. Ehret, and M. Grgas, Desvenlafaxine: another "me too" drug? Ann Pharmacother, 2008. 42(10): p. 1439-46.

Density	1.1±0.1 g/cm3
Boiling Point	403.8±25.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₅D₁₀NO₂
Molecular Weight	273.44
Flash Point	193.2±21.8 °C
Exact Mass	273.251312
LogP	2.26
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.573

Phenol, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl-2,2,3,3,4,4,5,5,6,6-d10)ethyl]-

4-{2-(Dimethylamino)-1-[1-hydroxy(2H10)cyclohexyl]ethyl}phenol

Desvenlafaxine-d10

Use of Desvenlafaxine-d10

Names

Desvenlafaxine-d10 Biological Activity

Chemical & Physical Properties

Synonyms