V-116517
Modify Date: 2024-01-04 19:23:57
V-116517 structure
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Common Name | V-116517 | ||
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| CAS Number | 1073616-61-1 | Molecular Weight | 442.819 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 679.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C19H18ClF3N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 364.6±31.5 °C | |
Use of V-116517V-116517 is a novel potent, selective, oral bioavailable TRPV1 antagonist with IC50 of 35.1 nM; shows high selectivity for TRPV1 over TRPV3 and TRPV4 (>10 uM) in a panel of 66 ion channels, receptors, transporters; dose-dependently reverses thermal hyperalgesia with ED50 of 2 mg/kg (p.o.) in acute inflammatory CFA model; shows excellent aqueous solubility, metabolic stability, oral bioavailability in multiple species, and excellent efficacy in a variety of animal pain models. Pain Phase 2 Clinical |
| Name | 3-Chloro-5-[(1S)-1,2-dihydroxyethyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-3',6'-dihydro-2,4'-bipyridine-1'(2'H)-carboxamide |
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| Synonym | More Synonyms |
| Description | V-116517 is a novel potent, selective, oral bioavailable TRPV1 antagonist with IC50 of 35.1 nM; shows high selectivity for TRPV1 over TRPV3 and TRPV4 (>10 uM) in a panel of 66 ion channels, receptors, transporters; dose-dependently reverses thermal hyperalgesia with ED50 of 2 mg/kg (p.o.) in acute inflammatory CFA model; shows excellent aqueous solubility, metabolic stability, oral bioavailability in multiple species, and excellent efficacy in a variety of animal pain models. Pain Phase 2 Clinical |
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| References | References 1. Tafesse L, et al. J Med Chem. 2014 Aug 14;57(15):6781-94. 2. Arendt-Nielsen L, et al. Pain. 2016 Sep;157(9):2057-67. View Related Products by Target TRP Channel Pain |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 679.3±55.0 °C at 760 mmHg |
| Molecular Formula | C19H18ClF3N4O3 |
| Molecular Weight | 442.819 |
| Flash Point | 364.6±31.5 °C |
| Exact Mass | 442.101959 |
| LogP | 0.47 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.624 |
| 3-Chloro-5-[(1S)-1,2-dihydroxyethyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-3',6'-dihydro-2,4'-bipyridine-1'(2'H)-carboxamide |
| [2,4'-Bipyridine]-1'(2'H)-carboxamide, 3-chloro-5-[(1S)-1,2-dihydroxyethyl]-3',6'-dihydro-N-[5-(trifluoromethyl)-2-pyridinyl]- |