G5
Modify Date: 2026-07-16 11:08:08
G5 structure
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Common Name | G5 | ||
|---|---|---|---|---|
| CAS Number | 108477-18-5 | Molecular Weight | 414.38900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H14N2O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of G5Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. |
| Name | 3,5-bis-((Ξ)-4-nitro-benzylidene)-1,1-dioxo-tetrahydro-1λ6-thiopyran-4-one |
|---|---|
| Synonym | More Synonyms |
| Description | Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. |
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| Related Catalog | |
| Target |
IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)[1] |
| In Vitro | G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of theinhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC50s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively[1]. |
| Cell Assay | Different drug concentrations are used to determine the dose-response profile and to calculate the IC50 value. Cells are incubated with the required concentrations of the 57 compounds. After 24 or 48 hours of incubation, cell death is evaluated bytr ypan blue staining[1]. |
| References |
| Molecular Formula | C19H14N2O7S |
|---|---|
| Molecular Weight | 414.38900 |
| Exact Mass | 414.05200 |
| PSA | 151.23000 |
| LogP | 5.09470 |
| InChIKey | SSAMIOWVUGBIJK-KAVGSWPWSA-N |
| SMILES | O=C1C(=Cc2ccc([N+](=O)[O-])cc2)CS(=O)(=O)CC1=Cc1ccc([N+](=O)[O-])cc1 |
| Storage condition | 2-8℃ |
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| 4h-thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide |
| ubiquitin isopeptidase inhibitor i, g5 |