LUMICHROME
LUMICHROME structure
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Common Name | LUMICHROME | ||
|---|---|---|---|---|
| CAS Number | 1086-80-2 | Molecular Weight | 242.23300 | |
| Density | 1.388g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C12H10N4O2 | Melting Point | 300 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of LUMICHROMELumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism[1][2]. |
Summary: LUMICHROME, Chinese name: 7,8-Dimethylisoindole, CAS number: 1086-80-2, molecular formula: C12H10N4O2, molecular weight: 242.23300, appears as a solid, melting point: 300 °C, density: 1.388g/cm3. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | lumichrome |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.388g/cm3 |
|---|---|
| Melting Point | 300 °C |
| Molecular Formula | C12H10N4O2 |
| Molecular Weight | 242.23300 |
| Exact Mass | 242.08000 |
| PSA | 91.50000 |
| LogP | 0.77640 |
| Index of Refraction | 1.66 |
| InChIKey | ZJTJUVIJVLLGSP-UHFFFAOYSA-N |
| SMILES | Cc1cc2nc3[nH]c(=O)[nH]c(=O)c3nc2cc1C |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Enhanced Indirect Photochemical Transformation of Histidine and Histamine through Association with Chromophoric Dissolved Organic Matter.
Environ. Sci. Technol. 49 , 5511-9, (2015) Photochemical transformations greatly affect the stability and fate of amino acids (AAs) in sunlit aquatic ecosystems. Whereas the direct phototransformation of dissolved AAs is well investigated, the... |
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The B vitamins nicotinamide (B3) and riboflavin (B2) stimulate metamorphosis in larvae of the deposit-feeding polychaete Capitella teleta: implications for a sensory ligand-gated ion channel.
PLoS ONE 9(11) , e109535, (2014) Marine sediments can contain B vitamins, presumably incorporated from settled, decaying phytoplankton and microorganisms associated with decomposition. Because B vitamins may be advantageous for the e... |
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Molecular and functional characterization of riboflavin specific transport system in rat brain capillary endothelial cells.
Brain Res. 1468 , 1-10, (2012) Riboflavin is an important water soluble vitamin (B2) required for metabolic reactions, normal cellular growth, differentiation and function. Mammalian brain cells cannot synthesize riboflavin and mus... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: USP8 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 8
External Id: USP8 FAST DUB HTS Primary
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Name: Experimentally measured binding affinity data (Kd) for protein-ligand complexes deriv...
Source: Shanghai Institute of Organic Chemistry
Target: N/A
External Id: PDBbind-Kd for protein-ligand complexes
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Name: USP17 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 17 like family member 5
External Id: USP17 FAST DUB HTS Primary
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Name: USP7 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 7
External Id: USP7 FAST DUB HTS Primary
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Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
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Name: Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL4296186
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Name: Assays to identify small molecules inhibitory for eIF4E expression
Source: 13133
Target: N/A
External Id: 20160513eIF4E
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Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262
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Name: Inhibition of Mycobacterium tuberculosis Uracil-DNA glycosylase using 5' 32P end-labe...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5623086
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Name: Inhibition of Mycobacterium tuberculosis Uracil-DNA glycosylase using 5'-FAM-CUUUUUGA...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5623087
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| MFCD00005021 |
| 7,8-Dimethylalloxazine |
| LUM |
| flavins |
| 7,8-dimethyl-1H-benzo[g]pteridine-2,4-dione |
| 6,7-DIMETHYLALLOXAZINE |
| EINECS 214-120-8 |
| Benzo[g]pteridine-2,4(1H,3H)-dione,7,8-dimethyl |
| 7,8-dimethyl-benzo[g]pteridine-2,4(1H,3H)-dione |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of lumichrome? |
| A: Molecular weight of lumichrome is 242.23300. |
| Q: What is the SMILES notation of lumichrome? |
| A: SMILES notation of lumichrome is Cc1cc2nc3[nH]c(=O)[nH]c(=O)c3nc2cc1C. |
| Q: What is the molecular formula of lumichrome? |
| A: Molecular formula of lumichrome is C12H10N4O2. |
| Q: What is the safety information for lumichrome? |
| A: Safety information for lumichrome: S24/25. |
| Q: What is the InChIKey of lumichrome? |
| A: InChIKey of lumichrome is ZJTJUVIJVLLGSP-UHFFFAOYSA-N. |
| Q: What is the LogP of lumichrome? |
| A: LogP of lumichrome is 0.77640. |
| Q: What are the uses of lumichrome? |
| A: Main uses of lumichrome: Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism[1][2]. |
| Q: What English synonyms does lumichrome have? |
| A: English synonyms of lumichrome: MFCD00005021, 7,8-Dimethylalloxazine, LUM, flavins, 7,8-dimethyl-1H-benzo[g]pteridine-2,4-dione, 6,7-DIMETHYLALLOXAZINE, EINECS 214-120-8, Benzo[g]pteridine-2,4(1H,3H)-dione,7,8-dimethyl, 7,8-dimethyl-benzo[g]pteridine-2,4(1H,3H)-dione. |
| Q: What is the melting point of lumichrome? |
| A: Melting point of lumichrome is 300 °C. |
| Q: What is the polar surface area (PSA) of lumichrome? |
| A: Polar surface area (PSA) of lumichrome is 91.50000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |