DNA gyrase inhibitor EN-7
Modify Date: 2024-04-06 22:43:37
DNA gyrase inhibitor EN-7 structure
|
Common Name | DNA gyrase inhibitor EN-7 | ||
|---|---|---|---|---|
| CAS Number | 1090842-69-5 | Molecular Weight | 384.395 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H16N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DNA gyrase inhibitor EN-7DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics.EN-7 inhibited growth of the wild-type strain (S. aureus) with MIC 1 μM.Strains containing GyrA A34T (mut-3 and mut-9), GyrA P219Q (mut-6), and GyrB K417E (mut-1, mut-2, mut-4, and mut-5) exhibited moderate resistance, with MICs of either 4 or 8 μM.EN-7 inhibited sporulation pathway in the bacterial genus Streptomyces. |
| Name | DNA gyrase inhibitor EN-7 |
|---|
| Description | DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics.EN-7 inhibited growth of the wild-type strain (S. aureus) with MIC 1 μM.Strains containing GyrA A34T (mut-3 and mut-9), GyrA P219Q (mut-6), and GyrB K417E (mut-1, mut-2, mut-4, and mut-5) exhibited moderate resistance, with MICs of either 4 or 8 μM.EN-7 inhibited sporulation pathway in the bacterial genus Streptomyces. |
|---|---|
| References | 1. McAuley S, et al. Cell Chem Biol. 2019 Sep 19;26(9):1274-1282.e4. |
| Molecular Formula | C22H16N4O3 |
|---|---|
| Molecular Weight | 384.395 |