1090842-69-5
1090842-69-5 structure
- Name: DNA gyrase inhibitor EN-7
- Chemical Name: DNA gyrase inhibitor EN-7
- CAS Number: 1090842-69-5
- Molecular Formula: C22H16N4O3
- Molecular Weight: 384.395
- Create Date: 2022-08-05 20:50:46
- Modify Date: 2024-04-06 22:43:37
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DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics.EN-7 inhibited growth of the wild-type strain (S. aureus) with MIC 1 μM.Strains containing GyrA A34T (mut-3 and mut-9), GyrA P219Q (mut-6), and GyrB K417E (mut-1, mut-2, mut-4, and mut-5) exhibited moderate resistance, with MICs of either 4 or 8 μM.EN-7 inhibited sporulation pathway in the bacterial genus Streptomyces.
| Name | DNA gyrase inhibitor EN-7 |
|---|
| Description | DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics.EN-7 inhibited growth of the wild-type strain (S. aureus) with MIC 1 μM.Strains containing GyrA A34T (mut-3 and mut-9), GyrA P219Q (mut-6), and GyrB K417E (mut-1, mut-2, mut-4, and mut-5) exhibited moderate resistance, with MICs of either 4 or 8 μM.EN-7 inhibited sporulation pathway in the bacterial genus Streptomyces. |
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| References | 1. McAuley S, et al. Cell Chem Biol. 2019 Sep 19;26(9):1274-1282.e4. |
| Molecular Formula | C22H16N4O3 |
|---|---|
| Molecular Weight | 384.395 |