ERK2 IN-1

Modify Date: 2024-01-10 00:36:36

ERK2 IN-1 Structure
ERK2 IN-1 structure
Common Name ERK2 IN-1
CAS Number 1093061-47-2 Molecular Weight 647.76
Density N/A Boiling Point N/A
Molecular Formula C36H34FN7O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ERK2 IN-1


ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM[1].

 Names

Name ERK2 IN-1

 ERK2 IN-1 Biological Activity

Description ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM[1].
Related Catalog
Target

ERK2:7 nM (IC50)

In Vitro ERK1/2 IN-1 (Compound 28) maintains good ERK enzymatic activity (ERK IC50=7 nM) and cellular activity in BRAF/KRAS mutant wildtype cancer cell lines (HT-29/Caspase IC50=118/80 nM)[1].
References

[1]. Boga SB, Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2029-2034.

 Chemical & Physical Properties

Molecular Formula C36H34FN7O2S
Molecular Weight 647.76
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