Roflupram

Modify Date: 2025-09-18 17:25:47

Roflupram structure	Common Name	Roflupram
	CAS Number	1093412-18-0	Molecular Weight	314.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₀F₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Roflupram

Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2].

Name	Roflupram

Description	Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	PDE4:26.2 nM (IC50)
References	[1]. Li D, et, al. Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway. Int Immunopharmacol. 2021 Jan;90:107176. [2]. You T, et, al. Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chem Neurosci. 2017 Nov 15;8(11):2381-2392.

Molecular Formula	C₁₆H₂₀F₂O₄
Molecular Weight	314.32
InChIKey	IXURVUHDDXFYDR-UHFFFAOYSA-N
SMILES	CC(C)CC(=O)c1ccc(OC(F)F)c(OC2CCOC2)c1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Roflupram
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Roflupram
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Roflupram

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Roflupram Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.