![]() 10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE structure
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Common Name | 10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE | ||
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CAS Number | 1094-08-2 | Molecular Weight | 348.93300 | |
Density | N/A | Boiling Point | 430.1ºC at 760 mmHg | |
Molecular Formula | C19H25ClN2S | Melting Point | 225 - 228 °C | |
MSDS | Chinese USA | Flash Point | 213.9ºC | |
Symbol |
![]() GHS07 |
Signal Word | Warning |
Use of 10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINEEthopropazine (Isothazine) hydrochloride is a potent, selective BChE inhibitor and a poor AChE inhibitor. Ethopropazine hydrochloride is a phenothiazine compound with anticholinergic properties. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease[1][2]. |
Name | profenamine hydrochloride |
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Synonym | More Synonyms |
Description | Ethopropazine (Isothazine) hydrochloride is a potent, selective BChE inhibitor and a poor AChE inhibitor. Ethopropazine hydrochloride is a phenothiazine compound with anticholinergic properties. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease[1][2]. |
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Related Catalog | |
Target |
BChE, AChE[2] |
References |
Boiling Point | 430.1ºC at 760 mmHg |
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Melting Point | 225 - 228 °C |
Molecular Formula | C19H25ClN2S |
Molecular Weight | 348.93300 |
Flash Point | 213.9ºC |
Exact Mass | 348.14300 |
PSA | 31.78000 |
LogP | 5.88660 |
Vapour Pressure | 1.34E-07mmHg at 25°C |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
EMBO Rep. 16 , 939-54, (2015) Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that PINK1 activates Parkin E3 ligase activity bot... |
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Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase.
Drug Metab. Dispos. 43 , 1218-25, (2015) Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previousl... |
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Linking a compound-heterozygous Parkin mutant (Q311R and A371T) to Parkinson's disease by using proteomic and molecular approaches.
Neurochem. Int. 85-86 , 1-13, (2015) Parkin is an E3-protein ubiquitin ligase, which plays an important role as a scavenger in cell metabolism. Since the discovery of the link between Parkin and Parkinson's disease, Parkin was placed in ... |
isothazinehydrochloride |
ProphenamineHCl |
parsidolhydrochloride |
EINECS 214-134-4 |
ethopropazine hydrochloride |
Profenaminhydrochlorid |
10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE |
parfezin |
lysivanehydrochloride |
ethopropazine hcl |
MFCD00012653 |