ARQ 621

Modify Date: 2025-08-28 09:08:48

ARQ 621 Structure
ARQ 621 structure
Common Name ARQ 621
CAS Number 1095253-39-6 Molecular Weight 552.427
Density 1.3±0.1 g/cm3 Boiling Point 730.6±70.0 °C at 760 mmHg
Molecular Formula C28H24Cl2FN5O2 Melting Point N/A
MSDS N/A Flash Point 395.7±35.7 °C

 Use of ARQ 621


ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity[1]. ARQ 621 is a kinesin inhibitor[2].

 Names

Name N-(3-aminopropyl)-N-[(1R)-1-(3-anilino-7-chloro-4-oxoquinazolin-2-yl)but-3-ynyl]-3-chloro-2-fluorobenzamide
Synonym More Synonyms

 ARQ 621 Biological Activity

Description ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity[1]. ARQ 621 is a kinesin inhibitor[2].
Related Catalog
Target

Eg5

In Vitro Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target[1].
References

[1]. L. C. Chen, et al. First-in-human study with ARQ 621, a novel inhibitor of Eg5: Final results from the solid tumors cohort.J Clin Oncol. 2011, May (20): 3076-3076.

[2]. Lindsay S Roberts, et al. Mapping Novel Metabolic Nodes Targeted by Anti-Cancer Drugs that Impair Triple-Negative Breast Cancer Pathogenicity. ACS Chem Biol. 2017 Apr 21;12(4):1133-1140.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 730.6±70.0 °C at 760 mmHg
Molecular Formula C28H24Cl2FN5O2
Molecular Weight 552.427
Flash Point 395.7±35.7 °C
Exact Mass 551.129089
PSA 93.25000
LogP 4.18
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.638
Storage condition -20℃

 Synonyms

Benzamide, N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylamino)-2-quinazolinyl]-3-butyn-1-yl]-2-fluoro-
N-(3-amino-propyl)-3-chloro-N-[(R)-1-(7-chloro-4-oxo-3-phenylamino-3,4-dihydro-quinazolin-2-yl)-but-3-ynyl]-2-fluoro-benzamide
ARQ-621
(R)-N-(3-aminopropyl)-3-chloro-N-(1-(7-chloro-4-oxo-3-(phenylamino)-3,4-dihydroquinazolin-2-yl)but-3-ynyl)-2-fluorobenzamide
N-(3-Aminopropyl)-N-[(1R)-1-(3-anilino-7-chloro-4-oxo-3,4-dihydro-2-quinazolinyl)-3-butyn-1-yl]-3-chloro-2-fluorobenzamide
ARQ 621
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