CGS 9343B
CGS 9343B structure
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Common Name | CGS 9343B | ||
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| CAS Number | 109826-27-9 | Molecular Weight | 544.60 | |
| Density | 1.31g/cm3 | Boiling Point | 778ºC at 760 mmHg | |
| Molecular Formula | C30H32N4O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 424.3ºC | |
Use of CGS 9343BZaldaride maleate (CGS-9343B) is a potent and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM[1][2]. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR[3]. |
| Name | CGS 9343B,1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-onemaleate |
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| Description | Zaldaride maleate (CGS-9343B) is a potent and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM[1][2]. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR[3]. |
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| Related Catalog | |
| Target |
IC50: 3.3 nM (calmodulin)[1][2]. |
| References |
| Density | 1.31g/cm3 |
|---|---|
| Boiling Point | 778ºC at 760 mmHg |
| Molecular Formula | C30H32N4O6 |
| Molecular Weight | 544.60 |
| Flash Point | 424.3ºC |
| Exact Mass | 544.23200 |
| PSA | 129.79000 |
| LogP | 3.85250 |
| Vapour Pressure | 1.78E-25mmHg at 25°C |
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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Calcium Signaling Is Required for Erythroid Enucleation.
PLoS ONE 11 , e0146201, (2016) Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing ... |
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The calmodulin inhibitor CGS 9343B inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells.
Toxicol. Appl. Pharmacol. 285 , 207-13, (2015) We investigated the effects of the calmodulin inhibitor CGS 9343B on voltage-dependent K(+) (Kv) channels using whole-cell patch clamp technique in freshly isolated rabbit coronary arterial smooth mus... |
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ATP hydrolysis is critically required for function of CaV1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.
J. Neurosci. 34(20) , 6843-8, (2014) Sound encoding is mediated by Ca(2+) influx-evoked release of glutamate at the ribbon synapse of inner hair cells. Here we studied the role of ATP in this process focusing on Ca(2+) current through Ca... |