NSAH
Modify Date: 2025-08-25 06:31:29
NSAH structure
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Common Name | NSAH | ||
|---|---|---|---|---|
| CAS Number | 1099592-35-4 | Molecular Weight | 306.315 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H14N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NSAHA nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM; has twofold IC50 of gemcitabine for growth inhibition of multiple cancer cell lines, while demonstrating little cytotoxicity against normal mobilized peripheral blood progenitor cells; depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells. |
| Name | 2-Hydroxy-1-naphthaldehyde salicyloylhydrazone |
|---|---|
| Synonym | More Synonyms |
| Description | A nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM; has twofold IC50 of gemcitabine for growth inhibition of multiple cancer cell lines, while demonstrating little cytotoxicity against normal mobilized peripheral blood progenitor cells; depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells. |
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| References | References 1. Ahmad MF, et al. Proc Natl Acad Sci U S A. 2017 Jul 17. pii: 201620220. View Related Products by Target Nucleoside Antimetabolite/Analog |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H14N2O3 |
| Molecular Weight | 306.315 |
| Exact Mass | 306.100433 |
| LogP | 6.08 |
| Index of Refraction | 1.647 |
| Hazard Codes | Xi |
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| 2-Hydroxy-N'-[(E)-(2-hydroxy-1-naphthyl)methylene]benzohydrazide |
| 2-Hydroxy-1-naphthaldehyde salicyloylhydrazone |
| Benzoic acid, 2-hydroxy-, ((2-hydroxy-1-naphthalenyl)methylene)hydrazide |
| Benzoic acid, 2-hydroxy-, 2-[(1E)-(2-hydroxy-1-naphthalenyl)methylene]hydrazide |
| 2-Hydroxy-N'-[(E)-(2-hydroxy-1-naphthyl)methylidene]benzohydrazide |