1099592-35-4

1099592-35-4 structure

Name: NSAH
Chemical Name: 2-Hydroxy-1-naphthaldehyde salicyloylhydrazone
CAS Number: 1099592-35-4
Molecular Formula: C₁₈H₁₄N₂O₃
Molecular Weight: 306.315
Create Date: 2020-01-11 19:27:05
Modify Date: 2025-08-25 06:31:29
A nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM; has twofold IC50 of gemcitabine for growth inhibition of multiple cancer cell lines, while demonstrating little cytotoxicity against normal mobilized peripheral blood progenitor cells; depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells.

Name	2-Hydroxy-1-naphthaldehyde salicyloylhydrazone
Synonyms	2-Hydroxy-N'-[(E)-(2-hydroxy-1-naphthyl)methylene]benzohydrazide 2-Hydroxy-1-naphthaldehyde salicyloylhydrazone Benzoic acid, 2-hydroxy-, ((2-hydroxy-1-naphthalenyl)methylene)hydrazide Benzoic acid, 2-hydroxy-, 2-[(1E)-(2-hydroxy-1-naphthalenyl)methylene]hydrazide 2-Hydroxy-N'-[(E)-(2-hydroxy-1-naphthyl)methylidene]benzohydrazide

Description	A nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM; has twofold IC50 of gemcitabine for growth inhibition of multiple cancer cell lines, while demonstrating little cytotoxicity against normal mobilized peripheral blood progenitor cells; depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells.
References	References 1. Ahmad MF, et al. Proc Natl Acad Sci U S A. 2017 Jul 17. pii: 201620220. View Related Products by Target Nucleoside Antimetabolite/Analog

Hazard Codes	Xi