Thiophene

Modify Date: 2024-01-02 17:53:01

Thiophene Structure
Thiophene structure
Common Name Thiophene
CAS Number 110-02-1 Molecular Weight 84.140
Density 1.1±0.1 g/cm3 Boiling Point 84.2±9.0 °C at 760 mmHg
Molecular Formula C4H4S Melting Point -38ºC
MSDS Chinese USA Flash Point -1.1±0.0 °C
Symbol GHS02 GHS05 GHS06 GHS08
GHS02, GHS05, GHS06, GHS08
Signal Word Danger

 Names

Name Thiophene
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 84.2±9.0 °C at 760 mmHg
Melting Point -38ºC
Molecular Formula C4H4S
Molecular Weight 84.140
Flash Point -1.1±0.0 °C
Exact Mass 84.003372
PSA 28.24000
LogP 1.90
Vapour density 2.9 (vs air)
Vapour Pressure 81.7±0.1 mmHg at 25°C
Index of Refraction 1.537
Storage condition Flammables area
Stability Stable. Highly flammable. Incompatible with strong oxidizing agents, nitrates.
Water Solubility INSOLUBLE

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XM7350000
CHEMICAL NAME :
Thiophene
CAS REGISTRY NUMBER :
110-02-1
BEILSTEIN REFERENCE NO. :
0103222
LAST UPDATED :
199710
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C4-H4-S
MOLECULAR WEIGHT :
84.14
WISWESSER LINE NOTATION :
T5SJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2000 ppm/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 8,141,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9500 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
830 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1089,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 mg/m3/24H/80D-C
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Endocrine - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(6),3,1967
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1010 mg/m3/6H/21W-I
TOXIC EFFECTS :
Liver - liver function tests impaired Endocrine - evidence of thyroid hyperfunction
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1010 mg/m3/6H/21W-I
TOXIC EFFECTS :
Liver - liver function tests impaired Endocrine - evidence of thyroid hyperfunction
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1010 mg/m3/6H/21W-I
TOXIC EFFECTS :
Liver - liver function tests impaired Endocrine - evidence of thyroid hyperfunction
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(2),57,1966 *** REVIEWS *** TOXICOLOGY REVIEW ATORAI A.P.I. Toxicological Review. (American Petroleum Institute, 2101 L St., NW, Washington, DC 20037) Volume(issue)/page/year: -,-,1948

 Safety Information

Symbol GHS02 GHS05 GHS06 GHS08
GHS02, GHS05, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H302-H315-H318-H331-H335-H340-H350
Precautionary Statements P201-P210-P261-P280-P305 + P351 + P338-P311
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes F:Flammable;Xn:Harmful;
Risk Phrases R11;R20/22;R36;R52/53
Safety Phrases S16-S36/37/39-S61
RIDADR UN 2414
WGK Germany 3
RTECS XM7350000
Packaging Group II
Hazard Class 3.0
HS Code 29349990

 Synthetic Route

~%

Thiophene Structure

Thiophene

CAS#:110-02-1

Literature: Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 239 - 244

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 29349990

 Articles12

More Articles
Structure-based drug design identifies polythiophenes as antiprion compounds.

Sci. Transl. Med. 7 , 299ra123, (2015)

Prions cause transmissible spongiform encephalopathies for which no treatment exists. Prions consist of PrP(Sc), a misfolded and aggregated form of the cellular prion protein (PrP(C)). We explore the ...

Ultra trace analysis of PAHs by designing simple injection of large amounts of analytes through the sample reconcentration on SPME fiber after magnetic solid phase extraction.

Talanta 147 , 59-62, (2015)

A simple solventless injection method was introduced based on the using of a solid-phase microextraction (SPME) fiber for injection of large amounts of the analytes extracted by the magnetic solid pha...

Two bisthienylethene-Ir(III) complexes showing acid/base-induced structural transformation and on-off luminescence switching in solution.

Dalton Trans. 44 , 21008-15, (2015)

Complexes [Ir(dfppy)2(pbdtiH)](PF6)·2CHCl3 (1-H) and [Ir(dfppy)2(pbdti)] (1) were synthesized by the reaction of bisthienylethene pbdtiH and an [Ir(dfppy)2Cl]2 dimer under neutral and basic conditions...

 Synonyms

Thiole
Thiacyclopentadiene
MFCD00005413
Thiofuran
EINECS 203-729-4
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