Tirilazad

Modify Date: 2024-01-09 23:43:19

Tirilazad structure	Common Name	Tirilazad
	CAS Number	110101-66-1	Molecular Weight	624.86
	Density	1.25g/cm3	Boiling Point	812.9ºC at 760mmHg
	Molecular Formula	C₃₈H₅₂N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	445.4ºC

Use of Tirilazad

Tirilazad is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad has antiviral activities against nCoV. Tirilazad is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].

Name	(8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
Synonym	More Synonyms

Description	Tirilazad is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad has antiviral activities against nCoV. Tirilazad is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Bath PM, et al. Tirilazad for acute ischaemic stroke. Cochrane Database Syst Rev. 2001;(4):CD002087. [2]. Zhang S, et al. Tirilazad for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD006778. [3]. Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee. Stroke. 2000 Sep;31(9):2257-65.

Description

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Bath PM, et al. Tirilazad for acute ischaemic stroke. Cochrane Database Syst Rev. 2001;(4):CD002087.

[2]. Zhang S, et al. Tirilazad for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD006778.

[3]. Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee. Stroke. 2000 Sep;31(9):2257-65.

Density	1.25g/cm3
Boiling Point	812.9ºC at 760mmHg
Molecular Formula	C₃₈H₅₂N₆O₂
Molecular Weight	624.86
Flash Point	445.4ºC
Exact Mass	624.41500
PSA	72.88000
LogP	5.59120
Vapour Pressure	1.71E-26mmHg at 25°C
Index of Refraction	1.646

Pregna-1,4,9(11)-triene-3,20-dione,21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)erazinyl)-16-methyl-,(16alpha)

tirilazad of tirilazad

Tirilazad

Tirilazad (INN)

Tirilazad [INN:BAN]

Tirilazadum

Tirilazadum [INN-Latin]

Tirilazad

Use of Tirilazad

Names

Tirilazad Biological Activity

Chemical & Physical Properties

Synonyms