Tirilazad

Modify Date: 2024-01-09 23:43:19

Tirilazad Structure
Tirilazad structure
Common Name Tirilazad
CAS Number 110101-66-1 Molecular Weight 624.86
Density 1.25g/cm3 Boiling Point 812.9ºC at 760mmHg
Molecular Formula C38H52N6O2 Melting Point N/A
MSDS N/A Flash Point 445.4ºC

 Use of Tirilazad


Tirilazad is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad has antiviral activities against nCoV. Tirilazad is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].

 Names

Name (8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
Synonym More Synonyms

 Tirilazad Biological Activity

Description Tirilazad is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad has antiviral activities against nCoV. Tirilazad is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].
Related Catalog
References

[1]. Bath PM, et al. Tirilazad for acute ischaemic stroke. Cochrane Database Syst Rev. 2001;(4):CD002087.

[2]. Zhang S, et al. Tirilazad for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD006778.

[3]. Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee. Stroke. 2000 Sep;31(9):2257-65.

 Chemical & Physical Properties

Density 1.25g/cm3
Boiling Point 812.9ºC at 760mmHg
Molecular Formula C38H52N6O2
Molecular Weight 624.86
Flash Point 445.4ºC
Exact Mass 624.41500
PSA 72.88000
LogP 5.59120
Vapour Pressure 1.71E-26mmHg at 25°C
Index of Refraction 1.646

 Synonyms

Pregna-1,4,9(11)-triene-3,20-dione,21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)erazinyl)-16-methyl-,(16alpha)
tirilazad of tirilazad
Tirilazad
Tirilazad (INN)
Tirilazad [INN:BAN]
Tirilazadum
Tirilazadum [INN-Latin]