HSR6071
Modify Date: 2024-01-09 18:54:04
HSR6071 structure
|
Common Name | HSR6071 | ||
|---|---|---|---|---|
| CAS Number | 111374-21-1 | Molecular Weight | 260.25500 | |
| Density | 1.555g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H12N8O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HSR6071HSR6071 is an antiallergic agent with potential for the treatment of asthma. |
| Name | 6-(1-Pyrrolidinyl)-N-(2H-tetrazol-5-yl)-2-pyrazinecarboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | HSR6071 is an antiallergic agent with potential for the treatment of asthma. |
|---|---|
| Related Catalog | |
| In Vivo | HSR-6071 suppresses antigen-induced histamine and SRS-A release from minced lung tissues of guinea-pigs sensitized passively with rabbit anti-EA serum and is a more potent inhibitor of the release of SRS-A than of histamine. On the other hand, histamine- or acetylcholine-induced bronchoconstriction in guinea-pigs is scarcely affected by HSR-6071 at doses sufficient to inhibit the experimental asthma, but LTD4-induced bronchoconstriction is dramatically inhibited. HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea[1]. HSR-6071 inhibits the IgE-mediated histamine release with an IC50 of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract[2]. |
| Animal Admin | Rats: In order to find out the proper pre treatment time with HSR-6071, 0.03 mg/kg, i.vi or 1 mg/kg, p.o. of HSR-6071 was given at varying times before the antigen challenge[2]. |
| References |
| Density | 1.555g/cm3 |
|---|---|
| Molecular Formula | C10H12N8O |
| Molecular Weight | 260.25500 |
| Exact Mass | 260.11300 |
| PSA | 116.07000 |
| LogP | 0.29120 |
| Index of Refraction | 1.717 |
| Storage condition | 2-8℃ |
|
~84%
HSR6071 CAS#:111374-21-1 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 1 p. 201 - 207 |
|
~%
HSR6071 CAS#:111374-21-1 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 1 p. 201 - 207 |
| 6-(1-Pyrazolyl)-2-quinolone |
| 2(1H)-Quinolinone,6-(1H-pyrazol-1-yl) |
| 6-(1-pyrrolidinyl)-N-(1H-tetrazol-5-yl)-2-pyrazine-5-carboxamide |
| HSR6071 |