Ochromycinone

Modify Date: 2024-01-09 12:24:28

Ochromycinone structure	Common Name	Ochromycinone
	CAS Number	111540-00-2	Molecular Weight	306.31200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ochromycinone

Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity[1][2].

Name	(+/-)-ochromycinone
Synonym	More Synonyms

Description	Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Anti-infection >> Bacterial
Target	STAT3
In Vitro	STA-21 inhibits STAT3 DNA binding activity, STAT3 dimerization, and STAT3-dependent luciferase activity. Moreover, STA-21 reduces the survival of breast carcinoma cells with constitutive STAT3 signaling but has minimal effect on the cells in which constitutive STAT3 signaling is absent[2].
References	[1]. Song H, et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4700-5. [2]. Nataliya I. Kalinovskaya, et al. New Angucyclinones from the Marine Mollusk Associated Actinomycete Saccharothrix espanaensis An 113. Natural product communications. 2008, 3(10):1611-1616.

Molecular Formula	C₁₉H₁₄O₄
Molecular Weight	306.31200
Exact Mass	306.08900
PSA	71.44000
LogP	2.93260
Storage condition	-20℃

ochromycinone

STA-021

Ochromycinon, 8-Hydroxy-3-methyl-1-oxo-1,2,3,4-tetrahydrobenz(a)anthrachinon

Ochromycinon, 8-Hydroxy-3-methyl-1-oxo-1,2,3,4-tetrahydrobenz[a]anthrachinon

STA-21

Ochromycinone

Use of Ochromycinone

Names

Ochromycinone Biological Activity

Chemical & Physical Properties

Synonyms